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The duration analysis of the experimental rabbit temporomandibular joint inflammation by the X ray in vivo micro CT for high-speed high resolution animals

高速高分辨率动物体内X射线显微CT对实验兔颞下颌关节炎症持续时间分析

基本信息

批准号：
18592069
负责人：
HONDA Kazuya
金额：
$ 2.44万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592069/
关键词：
temporomandibular ioint chronic arthritis micro CT 慢性顎関節炎

项目摘要

Objectives : To investigate the diagnostic accuracy of in vivo micro-computed tomography (micro-CT) for osseous abnormalities of the rat temporomandibular joint (TMJ) condyle, using macroscopic observations as the 'gold standardMethods : A 15 TMJ arthritis model was prepared by injecting inflammatory complete Freund's adjuvant (CFA) into one side of the TMJ cavities of rats. The TMJ condyles were then imaged using micro-CT. The samples were macroscopically evaluated for osseous abnormalities, including erosions, osteophytes, flattening, and concavity. The micro-CT images were independently assessed for abnormalities using the same criteria. Images in three planes and three-dimensional images were produced using the micro-XYZ and micro-3D modalities, respectively, of the micro-CT equipment. The performance of these imaging modalities was compared for rat condyles using the McNemar test.Results : According to the macroscopic observations, 12 of the 30 rat condyles showed osseous abnormalities. The micro-XYZ modality detected abnormalities in 11 of the condyles. The condyle diagnostic accuracy of micro-XYZ CT was 0.97, the sensitivity was 0.92, and the specificity was 1.0. The micro-3D modality detected abnormalities in 13 of the condyles. The condyle diagnostic accuracy of micro-3D CT was 0.97, the sensitivity was 1.0, and the specificity was 0.94. Conclusions : Good diagnostic results were obtained using the micro-XYZ and micro-3D modalities. Micro-CT is therefore an effective technique for the evaluation of osseous abnormalities in the rat TMJ condyle.

目的：以大体观察为金标准，探讨活体显微CT（micro-CT）对大鼠颞下颌关节（TMJ）髁突骨性异常诊断的准确性。方法：将炎性完全弗氏佐剂（CFA）注入大鼠一侧TMJ腔，制备15侧TMJ关节炎模型。然后使用micro-CT对TMJ髁状突进行成像。肉眼评价样本的骨质异常，包括侵蚀、骨赘、变平和骨质疏松。使用相同的标准独立评估micro-CT图像的异常。分别使用微型CT设备的微型XYZ和微型3D模态产生三个平面中的图像和三维图像。结果：根据肉眼观察，30个大鼠髁突中有12个显示骨性异常。微XYZ模态检测到11个髁突异常。micro-XYZ CT诊断髁突的准确性为0.97，敏感性为0.92，特异性为1.0。微3D模态检测到13个髁突的异常。微型三维CT诊断髁突的准确性为0.97，敏感性为1.0，特异性为0.94。结论：使用micro-XYZ和micro-3D模式获得了良好的诊断结果。因此，Micro-CT是评价大鼠颞下颌关节髁突骨质异常的有效技术。