Clarification of the physiological role of vasopressin in acute and chronic arthritis: using transgenic animals

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We examined the expression of the c-fos-mRFP1 fusion gene in dorsal horn of the spinal cord and the paraventricular nucleus after acute nociceptive stimulation by subcutaneous (s.c.) injection of formalin or TRPV4 agonist in hind paw of the c-fos-mRFP1 transgenic rats. We observed significant increases of mRFP1 fluorescence after s.c. injection of formalin or TRPV4 agonist. These transgenic rats are useful models to study central nervous system responses to nociceptive stress.