Analysis and clinical application of bone formation mechanism in immediate loading implant using materials driven by magnetic field

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The aim of this study was to clarify the mechanism of bone formation in immediate loading implants using material driven by magnetic field and apply this material as clinical instrument. To control the loading, we utilized vibration using mixture materials of epoxy resin and magnetic substance metals (cobalt ferrite powder) in this study. The magnetic field to vibrate the materials and implant was provided by alternating electric and magnetic field (magnetic field: 0.5 tesla, the distance between magnetic poles) (TEM-5000-G1, Toei, Sendai). This machine can control the magnetic field intensity (Max: 0.649 tesla) by output current. We implanted the titanium alloy (diameter: 1.0-1.2 mm, length 10-15 mm) in femur and tibia of male rats. In experimental group, an end of implant was exposed on skin, and the material driven by magnetic field was fixed on the exposed end of implant. By alternating electric and magnetic field, implant vibrated through the intervention of material driven by magnetic field. Histological sections were observed. In initial stage, fibrous or granulation tissue with slight inflammatory cells infiltration was observed around implant. However, in long term observation, new bone formation without inflammatory reaction was seen around the implant. Newly formed bone was observed on the surface of implant in experimental and control groups. The optimal vibration will induce the bone formation and the prompt arrangement of bone trabecular around the implant. Clinically, the development of vibratory device may contribute to stabilize the implant for long time. The new medical treatment using materials driven by magnetic field will apply in various medical fields due to less invasive therapies.