Genetic analysis of monoamine transporter and relation to the frequency of the nocturnal bruxism.

研究#1目的：睡眠磨牙症（SB）与颞下颌障碍（TMDs）之间的关系尚不清楚。本研究旨在估计青少年人群中SB的患病率，并探讨SB频率与TMD体征/症状患病率之间的关系。材料与方法：本研究招募高中一年级学生，共195名被试。将受试者按SB频次分为重度SB组和非重度SB组，接受临床检查和访谈。计算奇比（OR），通过多元回归分析检验SB频率性别差异与TMD体征/症状存在的关系。结果：重度SB与颞下颌关节粘连存在显著相关（OR: 3.74， P= 02），性别（男性）与颞下颌关节粘连存在无显著相关；重度SB与头痛无显著相关，性别（男性）与头痛存在显著相关（OR: 2.52， P= 04）。结论：青少年颞下颌关节的出现与严重SB的发生密切相关。研究#2目的：新型微型肌电分析仪（BiteStripR， S.L.P. Israel）在用于亚洲受试者时偶尔显示错误信息。为此，我们建立了version-up模型，本研究对这一修改进行了验证。方法：6名经便携式肌电图和视频记录诊断的重度磨牙志愿者参加了连续5晚的bitstrip记录。比较了错误信息的发生率。结果：版本升级系统的错误信息发生率（1/ 30,3.3%）显著低于常规系统（14/ 30,46.7%,p<0.01，卡方检验）。结论：这种修改能够减少错误信息的发生率。研究#3目的：考虑到日常波动，目前还没有关于磨牙评估有效性的研究。本研究旨在验证磨牙1晚、2晚和3晚的评估结果与连续10晚评估结果的对比。方法：对15例临床TMD患者连续10晚用牙条测量个体磨牙水平。以连续10夜结果的模式值为金标准。与现有金标准比较，计算1夜、2夜和3夜的效度。结果与总结：共有8例患者参加了本研究。1夜试验的敏感性为0.87 ~ 0.90，特异性为0.74 ~ 0.80，效度为0.82 ~ 0.88。这表明1夜试验可以证明适度的诊断准确性。少

RESEARCH #1Purpose: The relationship between sleep bruxism (SB) and temporomandibular disorders (TMDs) is unclear. This study aimed to estimate SB prevalence in an adolescent population and investigate the relationship between SB frequency and prevalence of the TMD signs/symptoms. Materials and Methods: First year high school students were recruited, and 195 subjects responded in this study. The subjects were divided into severe and non-severe SB groups with SB frequency and were received clinical examinations and interview. The odd-ratio (OR) were calculated to test the relationship between SB frequency gender difference and presence of the TMD signs/symptoms by multiple regression analysis. Results: Severe SB was significantly related to the presence of TMJ click (OR: 3.74, P= 02), while gender(male) was not related to that In contrast, severe SB was not related to headache, while gender (male)was significantly related to headache(OR: 2.52, P= 04). Conclusion: These results suggested … More that the presence of a TMJ click was closely related to the severe SB in an adolescent population.RESEARCH #2Objective: Novel miniature EMG analyzer (BiteStripR, S.L.P. Israel) occasionally showed error message when applied in Asian subjects. In response, the version-up model has been developed, and this study verified this modification. Methods: Six severe bruxism volunteers who had been diagnosed by portable electromyography and video recording participated this continuous 5-nights BiteStrip recording. The incidence rates of error message were compared. Results: The incidence of error message in the version-up systems (1/30, 3.3%) was significantly lower than that in the conventional system (14/30, 46.7%, p<0.01, Chi-square test). Conclusion: This modification was able to reduce the incidence of the error message.RESEARCH #3Objective: No research has been achieved regarding to the validity of bruxism assessment considering the daily fluctuation. This study aimed to verify the 1-night, 2-night and 3-night assessment of bruxism compared to the result of 10-straght night assessment. Methods: Fifteen TMD clinic patients were asked to measure individual bruxism level by means of using BiteStrip for 10 straight nights. The mode value of the result of 10-straight night was set as gold standard. The validity of 1-night test, 2-night test and 3-night test was calculated compared to prior gold standard. Result and summary: Totally 8 patients participated this study. The sensitivity, specificity and validity of 1-night test were 0.87-0.90, 0.74-0.80 and 0.82-0.88, respectively. This indicated the 1-night test could demonstrate the moderated diagnostic accuracy. Less