Genetic analysis of monoamine transporter and relation to the frequency of the nocturnal bruxism.

单胺转运蛋白的遗传分析及其与夜间磨牙频率的关系。

• 批准号: 18592122
• 负责人: MINAKUCHI Hajime
• 金额: $ 2.51万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592122/
• 关键词: Nocturnal bruxism; Temporomandibular disorders; Orofacial pain; Electromyography; Adolescent population; Epidemiological study; 慢性筋痛; 診断精度; 日差変動; 筋電計; 咀嚼筋痛; 簡易型筋電計; オッズ比

RESEARCH #1Purpose: The relationship between sleep bruxism (SB) and temporomandibular disorders (TMDs) is unclear. This study aimed to estimate SB prevalence in an adolescent population and investigate the relationship between SB frequency and prevalence of the TMD signs/symptoms. Materials and Methods: First year high school students were recruited, and 195 subjects responded in this study. The subjects were divided into severe and non-severe SB groups with SB frequency and were received clinical examinations and interview. The odd-ratio (OR) were calculated to test the relationship between SB frequency gender difference and presence of the TMD signs/symptoms by multiple regression analysis. Results: Severe SB was significantly related to the presence of TMJ click (OR: 3.74, P= 02), while gender(male) was not related to that In contrast, severe SB was not related to headache, while gender (male)was significantly related to headache(OR: 2.52, P= 04). Conclusion: These results suggested … More that the presence of a TMJ click was closely related to the severe SB in an adolescent population.RESEARCH #2Objective: Novel miniature EMG analyzer (BiteStripR, S.L.P. Israel) occasionally showed error message when applied in Asian subjects. In response, the version-up model has been developed, and this study verified this modification. Methods: Six severe bruxism volunteers who had been diagnosed by portable electromyography and video recording participated this continuous 5-nights BiteStrip recording. The incidence rates of error message were compared. Results: The incidence of error message in the version-up systems (1/30, 3.3%) was significantly lower than that in the conventional system (14/30, 46.7%, p<0.01, Chi-square test). Conclusion: This modification was able to reduce the incidence of the error message.RESEARCH #3Objective: No research has been achieved regarding to the validity of bruxism assessment considering the daily fluctuation. This study aimed to verify the 1-night, 2-night and 3-night assessment of bruxism compared to the result of 10-straght night assessment. Methods: Fifteen TMD clinic patients were asked to measure individual bruxism level by means of using BiteStrip for 10 straight nights. The mode value of the result of 10-straight night was set as gold standard. The validity of 1-night test, 2-night test and 3-night test was calculated compared to prior gold standard. Result and summary: Totally 8 patients participated this study. The sensitivity, specificity and validity of 1-night test were 0.87-0.90, 0.74-0.80 and 0.82-0.88, respectively. This indicated the 1-night test could demonstrate the moderated diagnostic accuracy. Less

研究#1目的：睡眠磨牙症（SB）和颞下颌关节紊乱病（TMD）之间的关系尚不清楚。本研究旨在评估青少年人群中SB的患病率，并调查SB频率与TMD体征/症状患病率之间的关系。材料与方法：以高中一年级学生为研究对象，共195名被试参与研究。根据SB发生频率将受试者分为重度SB组和非重度SB组，并接受临床检查和访谈。采用多元回归分析方法，计算SB发生率与TMD症状/体征的比值比（OR），分析SB发生率与TMD症状/体征的关系。结果如下：重度SB与颞下颌关节咔嗒声的发生显著相关（OR：3.74，P= 0.02），而性别（男性）与颞下颌关节咔嗒声的发生无关。重度SB与头痛无关，而性别（男性）与头痛显著相关（OR：2.52，P= 0.04）。结论：这些结果提示 ...更多信息 研究#2目的：新型微型EMG分析仪（BiteStripR，S. L. P. Israel）在应用于亚洲受试者时偶尔显示错误信息。作为回应，版本升级模型已经开发出来，本研究验证了这一修改。研究方法：6名通过便携式肌电图和视频记录诊断为重度磨牙症的志愿者参加了连续5晚的BiteStrip记录。比较两组错误信息的发生率。结果如下：版本升级系统的错误信息发生率（1/30，3.3%）显著低于传统系统（14/30，46.7%，p<0.01，卡方检验）。结论：研究#3目的：没有研究已经取得了关于磨牙症评估的有效性，考虑到每天的波动。本研究的目的是验证1夜，2夜和3夜的磨牙症的评估相比，10直夜评估的结果。方法：对15例TMD门诊患者连续10个晚上使用BiteStrip测试个体磨牙水平。以连续10夜结果的众数为金标准。与先前的金标准相比，计算1晚测试、2晚测试和3晚测试的有效性。结果与总结：共8例患者参加了本研究。一夜试验的敏感性为0.87-0.90，特异性为0.74-0.80，有效性为0.82-0.88。这表明1夜试验可以证明中等诊断准确性。少

项目成果

Relationship between the frequency of sleep bruxism and the prevalence of signs and symptoms of temporomandibular disorders in an adolescent population.

青少年群体中睡眠磨牙的频率与颞下颌疾病体征和症状的患病率之间的关系。

• 期刊: INTERNATIONAL JOURNAL of PROSTHODONTICS (In press)
• 作者: Chiyomi Nagamatsu-Sakaguchi;Hajime Minakuchi;Glenn T. Clark and Takuo Kuboki.
• 通讯作者: Glenn T. Clark and Takuo Kuboki.

簡易貼付型ブラキシズム測定装置の現状と今後

简单粘贴式磨牙症测量装置的现状和未来

• 发表时间: 2007
• 作者: Y.Suzuki;S.Kamakura;K.Sasaki;S.Kokubun;O.Suzuki et al.;水口 一
• 通讯作者: 水口 一

被験者の自覚や家族の指摘のみで睡眠時ブラキシズムは診断できるか?

是否可以仅根据受试者的意识或家庭成员的指示来诊断睡眠磨牙症？

• 发表时间: 2007
• 作者: 坂口(永松)千代美;他
• 通讯作者: 他

Version upgrade of miniature bruxism detection device and its quantitative assessment

微型磨牙症检测仪的版本升级及其定量评估

• 发表时间: 2006
• 作者: Hajime;Minakuchi;Chiyomi;Nagamatsu;Kenji;Maekawa;Manabu;Kanyama;Yoshizo;Matsuka;Takuo;Kuboki;GT.;Clark
• 通讯作者: Clark

Relationship between severity of sleep bruxism and prevalence of TMD signs and symptoms in an adolescent population.

青少年睡眠磨牙症严重程度与 TMD 体征和症状患病率之间的关系。

• 发表时间: 2006
• 作者: Nagamatsu C;Minakuchi H;Maekawa K;Kanyama M;Matsuka Y;Kuboki T.
• 通讯作者: Kuboki T.