Expermentae research of prefabricafed enyincerd of bane tissue with blood vessel handle which uses existing blood vessel bunch in vivo

利用体内现有血管束预制带血管手柄的害虫组织套的实验研究

• 批准号: 18592195
• 负责人: YAMASITA Yoshihiro
• 金额: $ 1.94万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592195/
• 关键词: Regenerative medicine; Reconstructive sureer; Tissue engineering

The aim of this study was To do an artificial material necessary for a blood vessel bunch surroundings in vivo for reproducing the bone organization, to use the method of reproducing the bone organization with an artificial blood vessel handle, and to examine the possibility of an actual clinical application and it was researched to transplant the bone organization with the blood vessel handle actually played to the mandibular bone by using a large-scale animal among the same animals, and to examine stability of the reproducing bone.1. The reproduction bone with the blood vessel handle which makes β-TCP a work stand is made the use of AV shunt loop of the Hiroga movements pulse.It experimented on chamber (research representative making)which made β-TCP done as follows by making, and the Nainu beagle and 16 male use. The crowd which observed the reproduction bone: It divided into eight crowds which reproduced the jawbone by using the reproduction bone with eight. Moreover, the crowd whi … More ch observed the reproduction bone: PRP administering group of eight: 4 and non-administering group: It was assumed four. In addition, it similarly went to the PRP administering group and non-administering group by using the reproduction bone in eight crowds which reproduced the jawbone.2. Analysis of reproduction boneIt was made to be euthanatized in 1.8 six months later and chamber was removed from the Hiroshi line of the backbone on both sides under. At this time, even the armpit movements pulse flaked off, and the Cabtocda movements pulse was removed with chamber.2. The catheter is inserted from the cutting edge of the movements pulse at the same time as removing chamber, the angiography medicine (sulfuric acid Barriyum of the gelatin content 5%60% and Urografin) is administered, and a newborn blood vessel in the reproduction bone is confirmed by X rays of taking a picture.3. After it took a picture of X rays of, escape ash H-E dye specimen was made, and this specimen material was retrieved in histology. As a result, β-TCP which did in each crowd admitted absorbing, and the substitution of the fiber externals cell was admitted.5. It makes comparative study of area of a newborn blood vessel in the reproduction bone and amount (V) of the reproduction bone organization in the PRP administering group and non-administering group and the immunity histochemistry to the fiber externals cell that was substituted for the bamboo whisk in the future is retrieved. As for the presence of the bone inducement cell and the difference of the Cotskei performance in each amount, it was, and the formed reproduction bone was the separation bones of the examination with the blood vessel handle which was able to be transplanted.3. Transplant of beagle of reproduction bone with blood vessel handle to mandibular boneThe thrombus was admitted when blood tube was combined in all samples and the causing life wear was not admitted though the reproduction bone was transplanted to mandibular bone of four beagle dogs. Less

本研究的目的是为了制造用于再生骨组织的体内血管束周围所必需的人工材料，使用具有人工血管柄的骨组织再生方法，并检查实际临床应用的可能性，研究了通过使用同一动物中的大型动物，并检查繁殖骨骼的稳定性。1.利用Hiroga运动脉冲的AV分流环制作了使β-TCP成为工作台的带血管柄的再生骨，通过制作制作β-TCP的腔室（研究代表制作）进行了如下实验，并在Nainu比格犬和16只雄性使用。观察组：用8块再生骨进行颌骨再生，共分为8组。此外，人群whi ...更多信息 ch观察生殖骨：PRP给药组8只：4只，非给药组：假定4只。此外，在8个颌骨再生人群中，PRP给药组和非给药组的再生骨相似.生殖骨分析在1.8个月后将其安乐死，并从两侧脊柱的Hiroshi线下取出腔室。此时，甚至腋窝运动脉搏也剥落，Cabtocda运动脉搏也被腔室消除。2.在取出腔室的同时，从运动脉冲的切割边缘插入导管，施用血管造影药物（明胶含量为5%60%的硫酸Barriyum和Urografin），并通过拍摄照片的X射线确认再生骨中的新生血管。3.拍摄X线片后，制作逃逸灰H-E染料标本，并对标本材料进行组织学检查。结果表明，β-TCP在各人群中的吸收均被认可，并认可了纤维外细胞的替代作用.对PRP给药组和非给药组的生殖骨中新生血管的面积和生殖骨组织的量（V）进行比较研究，并检索到对将来替代竹鞭的纤维外膜细胞的免疫组织化学。至于骨诱导细胞的存在和各量Cotskei性能的差异，均为，形成的再生骨为带血管柄的分离骨，可移植.将带血管柄的生殖骨移植到比格犬下颌骨中，对4只比格犬下颌骨进行了生殖骨移植，所有标本均在结合血管时发现血栓，未发现引起生命磨损的因素。少

项目成果

Expressio of galectin-3 in oral squamous carocinomas

半乳糖凝集素3在口腔鳞癌中的表达

• 发表时间: 2007
• 作者: Yamahita Y.;Zang M.;Yamamoto H.;Kurokawa H;Fukuyama H.;Takahashi T.
• 通讯作者: Takahashi T.

Stage I，II舌扁平上皮癌における周辺上皮の上皮性異形成について

I、II期舌鳞状细胞癌周围上皮上皮发育不良

• DOI: 10.5981/jjhnc.32.455
• 发表时间: 2006
• 作者: 英雄 黒川;善弘 山下;忍 松本;哲郎 高橋;隅男 迫田
• 通讯作者: 隅男 迫田

Clinico-pathological analysis of odontogenic tumours according to revised WHO(2005) histopathological classification in Japanese

根据日本修订的 WHO（2005）组织病理学分类对牙源性肿瘤进行临床病理学分析

• 发表时间: 2007
• 期刊: J. Kyushyu Dent. Soc 61
• 作者: Zhang;M.;Fukuyama;H.;Matsuo;K.;Yamashita;Y.;Hirashima;S.;Takahashi;T.;Fukuda;J
• 通讯作者: J

Clinico-pathological analysis of odontogenic tumours according to revised WHO(2005)histo pathological classification in Japanese

根据修订后的日本 WHO（2005）组织病理学分类对牙源性肿瘤进行临床病理分析

• 发表时间: 2007
• 期刊: J.Kyushyu Dent.Soc.61:55-66, 2007 61
• 作者: Zhang M.;Fukuyama H.;Matsuo K.;Yamashita Y.;Hirashima S.;Talahashi T.;Fukuda J.
• 通讯作者: Fukuda J.

Study of mucosalization of free flaps in oral cavity

口腔游离皮瓣粘膜化的研究

• 发表时间: 2007
• 作者: Yamashita Y.;Yamauti K.;Yostuoka I.;Tomoyose T.;Tominaga K.;Thang M.;Matuo K.;Fukuyama H.;Fukuda J.;Takahashi T
• 通讯作者: Takahashi T