Regulatory effects of methoxyphenols on the transcription factor activation in mammalian cells.

我们研究了甲氧基酚类物质如BHA、双BHA、邻香兰素、愈创木酚、姜黄素、四氢姜黄素、酚和双酚对LPS或其他刺激物刺激的哺乳动物细胞转录因子激活的调节作用。几乎不从酚羟基中提取H原子的甲氧基酚抑制氧化还原敏感转录因子的转录活性，抑制COX-2和细胞因子的表达。这些观察结果表明，甲氧基酚化合物通过其酚功能具有治疗慢性炎症和诱变的潜力。

We investigated the regulatory effects of methoxyphenols such as BHA, bis-BHA, o-vanillin, guaiacol, curcumin, tetrahydrocurcumin, phenol and biphenol, on the transcription factor activation stimulated by LPS or other stimulants in mammalian cells. Methoxyphenols which hardly abstracted an H atom from the phenolic OH group inhibited a transcriptional activity of redox-sensitive transcription factors, and suppressed COX-2 and cytokine expression. These observations suggested that methoxyphenol compounds possessed a therapeutic potential against chronic inflammation and mutagenesis by its phenol function.