Development of an antilymphangiogenesis through the regulation of NFtB signaling in oral cancer

通过调节口腔癌中的 NFtB 信号传导来开发抗淋巴管生成药物

• 批准号: 18592221
• 负责人: AZUMA Masayuki
• 金额: $ 2.53万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592221/
• 关键词: oral cancer; VEGF; lymph vessel; metastasis; NE-KB; proteasome inhibitor

I have obtained the following results in the period of this research :1. By the analysis of oral cancer tissues of the patients with or without metastatic lymph node, it was shown that the number of lymph vessels and PCNA positive cells in the lymph vessels of the patients with metastaticlymph node were significantly higher than those in patients without metastaticlymph node ;2. I have already demonstrated that NE-KB only regulates the expression of VEGF-A in the VEGF isoforms. Therefore, the relation between the expression of VEGF-A in tumor tissues and the lymph node metastasis was evident in oral cancer patients ;3. By using the real-time RT-PCR analysis, expression of VEGF-A mRNA showed a high level in 2 of 3 freshly isolated tumor tissues as compared to those in normal mucosal tissues ;4. It has been suggested that the mode of tumor invasion (Y-K classification) was correlated with the number of lymph vessels in tumor tissues.

1.通过对有或无淋巴结转移患者口腔癌组织的分析，发现有淋巴结转移患者的淋巴管数量和淋巴管内的增殖细胞核抗原阳性细胞数均显著高于无转移淋巴结患者；2.已证实NE-KB仅对VEGF亚型中的VEGF-A的表达有调节作用。因此，口腔癌患者肿瘤组织中VEGF-A的表达与淋巴结转移的关系是明显的；3.实时定量RT-PCR分析显示，3例新鲜分离的肿瘤组织中有2例表达水平高于正常黏膜组织；4.肿瘤的侵袭方式(Y-K分级)与肿瘤组织中淋巴管的数量有关。

项目成果

Therapeutic effect of bortezomib mono-therapy for the treatment of oral cancer

硼替佐米单药治疗口腔癌的疗效

• 发表时间: 2007
• 作者: Azuma;Masayuki
• 通讯作者: Masayuki

Establishment of BDNF-TrkB paracrine system by two clonal cells derived from a human oral squamous cell carcinoma.

通过源自人口腔鳞状细胞癌的两个克隆细胞建立 BDNF-TrkB 旁分泌系统。

• 发表时间: 2007
• 作者: Harada;Kouji;Uchida Daisuke;Onoue Tmitarou;Bando Takashi
• 通讯作者: Bando Takashi

Suppression of aquaporin-5 expression by TNF-a in human salivary acinar cells

TNF-a 对人唾液腺泡细胞中水通道蛋白 5 表达的抑制

• 发表时间: 2007
• 作者: Motegi;Katsumi
• 通讯作者: Katsumi

Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-κB activity in human oralsquamous cell carcinoma cells

千金藤素通过抑制人口腔鳞状细胞癌细胞中辐射诱导的核因子-κB 活性来增强放射敏感性

• 发表时间: 2007
• 期刊: International Journal of Oncology (in press)
• 作者: Takahashi I;Masuda T;et. al.;Tamatani Tetsuya
• 通讯作者: Tamatani Tetsuya

Augmentation of anti-tumor effect of TS-1 by cepharanthin in the treatment of oral squamous cell carcinoma

千金藤素增强TS-1治疗口腔鳞状细胞癌的抗肿瘤作用

• 发表时间: 2007
• 作者: Harada;Kouji
• 通讯作者: Kouji