Prediction of the Protein O-glycosylation site by Neural Networks and Support Vector Machine

通过神经网络和支持向量机预测蛋白质O-糖基化位点

基本信息

  • 批准号:
    19300080
  • 负责人:
  • 金额:
    $ 12.31万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2007
  • 资助国家:
    日本
  • 起止时间:
    2007 至 2009
  • 项目状态:
    已结题

项目摘要

O-Glycosylation sites in the mammalian protein is predicted by the machine learning to elucidate the glycosylation mechanisms. Especially, the crowded and the isolated glycosylation sites are separately considered, and it is found that the former is affected by the amino acid composition of the neighboring sites while the latter is affected by the amino acid sequence, and more detailed characteristics are investigated. O-Glycosylation sites are often found in the intrinsically disordered proteins, which lead to the biological understandings of the conservation property, the role in the structural stability and so on. Biological experiments are also executed for a verification of the prediction.
通过机器学习预测哺乳动物蛋白中的o -糖基化位点,以阐明糖基化机制。特别是,将拥挤的糖基化位点和孤立的糖基化位点分开考虑,发现前者受邻近位点氨基酸组成的影响,后者受氨基酸序列的影响,并对其更详细的特征进行了研究。o -糖基化位点经常出现在内在无序的蛋白质中,这导致了对其保护特性、在结构稳定性中的作用等的生物学理解。为了验证预测,还进行了生物实验。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Generalized N-Dimensional Principal Component Analysis (GND-PCA) Based Statistical Appearance Modeling of Facial Images with Multiple Modes
  • DOI:
    10.2197/ipsjtcva.1.231
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Xu Qiao;R. Xu;Yenwei Chen;T. Igarashi;K. Nakao;A. Kashimoto
  • 通讯作者:
    Xu Qiao;R. Xu;Yenwei Chen;T. Igarashi;K. Nakao;A. Kashimoto
Computer-Assisted Preoperative Planning for Reduction of Proximal Femoral Fracture Using 3-D-CT Data
Sphingomyelins in Four Ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava.
四海鞘、海鞘、Halocynthia roretzi、Halocynthia aurantium 和 Styela clava 中的鞘磷脂。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Masahiro Ito;Kazuhito Yokoi;Takashi Inoue;Shogo Asano;Rei Hatano;Ryota Shinohara;Saki Itonori;Mutsumi Sugita
  • 通讯作者:
    Mutsumi Sugita
A spatio-chromatic ICA Based noise reduction in color images
基于空间色 ICA 的彩色图像降噪
Image Categorization by Learned PCA Subspace of Combined Visual-words and Low-level Features
通过组合视觉词和低级特征的学习 PCA 子空间进行图像分类
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Xianhua Han;Yen-Wei Chen
  • 通讯作者:
    Yen-Wei Chen
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NISHIKAWA Ikuko其他文献

NISHIKAWA Ikuko的其他文献

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{{ truncateString('NISHIKAWA Ikuko', 18)}}的其他基金

Development, Evaluation and Application of Multi-objective Optimization Methods by Genetic Algorithms
遗传算法多目标优化方法的开发、评估和应用
  • 批准号:
    12680402
  • 财政年份:
    2000
  • 资助金额:
    $ 12.31万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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