Neural circuit mechanisms of behavioral control through striatal projection pathways
Neural circuit mechanisms of behavioral control through striatal projection pathways
批准号:
19300109
负责人:
KOBAYASHI Kazuto
金额:
$9.82万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In the present study, we addressed the behavioral and physiological roles of these two pathways in the performance of conditional discrimination task. The analysis of the transgenic mice that deleted the striatonigral pathway indicated that the striatonigral pathway is mainly involved in the facilitation of speed of learned motor response but does not affect the accuracy of response selection. In addition, the analysis of the transgenic rats that lacked the striatopallidal pathway revealed that the striatopallidal pathway plays an important role in the accuracy of response selection but does not influence speed of motor response in conditional discrimination task.
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Selective loss of nigral dopamine neurons induced by overexpression of truncated human a-synuclein in mice.
小鼠中截短的人α-突触核蛋白过度表达诱导黑质多巴胺神经元的选择性丧失。
DOI:
--
发表时间:
2008
期刊:
Neurobiol. Aging. 29(4)
影响因子:
--
作者:
[Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S, Kobayashi K, Iwatsubo T and Yoshimoto M]
通讯作者:
Iwatsubo T and Yoshimoto M
ドーパミン伝達による行動発現システムの制御
通过多巴胺传递控制行为表达系统
DOI:
--
发表时间:
2008
期刊:
蛋白質核酸酵素 53
影响因子:
--
作者:
[甲斐 信行, 小林 和人]
通讯作者:
小林 和人
Generating animal models for the central nervous system diseases by immunotoxin cell targeting
通过免疫毒素细胞靶向建立中枢神经系统疾病动物模型
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kobayashi, K., Okada, K.]
通讯作者:
K.
Unexpected expression of a-and b-globin in mesencephalic dopaminergic neurons and glial cells.
中脑多巴胺能神经元和神经胶质细胞中 a 珠蛋白和 b 珠蛋白的意外表达。
DOI:
--
发表时间:
2009
期刊:
Proc. Natl. Acad. Sci. USA 106(36)
影响因子:
--
作者:
[Biagioli, M., Pinto, M., Cesselli, D., Zaninello, M., Lazarevic, D., Simone, R., Vlachouli, C., Plessy, C., Bertin, N., Beltrami, A., Kobayashi, K., Gallo, V., Ferrer, I., Santoro, C., Rivella, S., Beltrami, C.A., Carninci, P., Raviola, E., Gustincich, S.]
通讯作者:
S.
イムノトキシン細胞標的法
免疫毒素细胞靶向方法
DOI:
--
发表时间:
2008
期刊:
実験医学 26
影响因子:
--
作者:
[小林和人, 深堀良二]
通讯作者:
深堀良二
共 11 条
The roles of CREBH in non-alcoholic fatty liver
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批准号:26500001
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财政年份:2014
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负责人:KOBAYASHI Kazuto
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Development of genetic manipulation technology for excitatory and inhibitory control of the target neuron activity
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财政年份:2010
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负责人:KOBAYASHI Kazuto
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依托单位:
The autoloop pathogenic mechanism of diabetic complication by SREBP-1c
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批准号:20591043
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资助金额:$2.91万
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财政年份:2008
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负责人:KOBAYASHI Kazuto
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依托单位:
Behavioral and physiological roles of the striatal GABAergic interneuronal types
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批准号:16300102
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:2004
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负责人:KOBAYASHI Kazuto
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依托单位:
Molecular and cellular mechanisms underlying catecholaminergic regulation of higher brain functions
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批准号:11480231
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:1999
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负责人:KOBAYASHI Kazuto
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依托单位:
Mouse genetic studies on the functions of the mammalian catecholaminergic nervous system
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批准号:06454182
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.93万
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财政年份:1994
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负责人:KOBAYASHI Kazuto
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依托单位:
海外基金