Research and development of a therapeutic exercise preconditioning for muscle atrophy and circulatory failure with non-insulin-dependent diabetes mellitus

非胰岛素依赖型糖尿病肌肉萎缩和循环衰竭治疗性运动预处理的研究与开发

• 批准号: 19300196
• 负责人: TAKEDA Isao
• 金额: $ 11.9万
• 依托单位: Himeji Dokkyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300196/
• 关键词: リハビリテーション; 運動療法; 糖尿病; 微小循環; プレコンディショニング; 筋萎縮; 運動; 血管構造

Exercise training has long been utilized as one of therapy in the non-insulin-dependent diabetes mellitus. The effects of a therapeutic exercise preconditioning on the myocyte and the microcirculation of skeletal muscle in diabetic rats was investigated. The preconditioning consisted of exercise at either low-(aerobic) or Hi-(unaerobic) intensity and included five 60 or 30 min sessions per week for 3 weeks, respectively. Both treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. The capillary volume in diabetic muscle was significantly less, i.e., capillary regression. In three exercise-trained diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.

长期以来，运动训练一直是治疗非胰岛素依赖型糖尿病的一种方法。研究了治疗性运动预处理对糖尿病大鼠骨骼肌肌细胞和微循环的影响。预处理包括低（有氧）或高（无有氧）强度的运动，每周分别进行5次60分钟或30分钟的运动，持续3周。与糖尿病大鼠相比，两种治疗的糖尿病大鼠的血浆葡萄糖、糖蛋白和活性氧（ROS）均有所下降，但并未完全恢复正常水平。糖尿病肌肉毛细血管体积明显减小，即毛细血管萎缩。在三个运动训练的糖尿病肌肉中，毛细血管体积向控制水平增加，并完全正常。总之，本研究结果为运动训练在减少与糖尿病相关的一些肌肉循环并发症方面的有效性提供了证据。

项目成果

地域在住女性高齢者の開眼片足立ち保持時間と身体機能との関係

社区老年妇女单腿睁眼站立时间与身体机能的关系

• 发表时间: 2008
• 期刊: 理学療法科学 23
• 作者: 村田 伸;大山 美智江;太田 尾浩;村田 潤;豊田 謙二;藤野 英己;弓岡 光徳;武田 功
• 通讯作者: 武田 功

Lack of exercise,via hindlimb suspension,impedes endogenous neurogenests

缺乏运动，通过后肢悬吊，阻碍内源性神经发生

• 发表时间: 2007
• 期刊: Neurocience 149
• 作者: Yasuhara T;Hara K;Maki M;Matsukawa N;Fujino H;Date I;Borlongan CV.
• 通讯作者: Borlongan CV.

Responses of pro- and anti-angiogenic factors to capillary in rat soleus muscle after hindlimb unloading

后肢卸载后促血管生成因子和抗血管生成因子对大鼠比目鱼肌毛细血管的反应

• 发表时间: 2009
• 作者: Fujino H;Kondo H;Murakami S;Nagatomo F;Takeda I;Ishihara A
• 通讯作者: Ishihara A

Microvascular remodeling and decreased angiogenic factors in the atrophied rat soleus muscle

萎缩大鼠比目鱼肌中的微血管重塑和血管生成因子减少

• 发表时间: 2008
• 作者: Fujino H;Ishihara A;Murakami S;Kondo H;Takeda I;Tillakat atne NJ;Zhong H;Roy RR;Edgerton VR
• 通讯作者: Edgerton VR

Fiber capillary regression and endothelial apoptosis against disuse atrophy in rat soleus muscle: role of angiogenic regulators

毛细血管退化和内皮细胞凋亡对抗大鼠比目鱼肌废用性萎缩：血管生成调节剂的作用

• 发表时间: 2010
• 作者: Fujino H;Kondo H;Murakami S;Nagatomo F;Takeda I;Ishihara A;Roy RR
• 通讯作者: Roy RR