Observation of Mosquito's Penetrating Motion and Its Application to Microneedle for Low-invasive Medical Treatment

蚊虫穿透运动的观察及其在微针微创治疗中的应用

• 批准号: 19310091
• 负责人: AOYAGI Seiji
• 金额: $ 12.81万
• 依托单位: Kansai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19310091/
• 关键词: 蚊; 穿刺行動観察; 穿刺メカニズム; 医療用マイクロニードル; マイクロマシニング

Aiming at use for low-invasive medical treatment, development of microneedle imitating mosquito's proboscis using MEMS technology was proposed. A penetrating motion of mosquito's proboscis to a transparent thin skin of laboratory lat was observed by a magnifying lens and high-speed camera system. Following facts were confirmed by the observation : (a) two maxillas are inserted to human skin organism, playing a role of anchor. (b) Labium is inserted to the space between two maxillas. The procedures of (a) and (b) are cyclically repeated, while the proboscis progresses deeper inside the object. Also various parameters were quantitatively evaluated such as insertion speed, cycle time, etc. Considering insertion mechanism of mosquito's proboscis using both dynamic FEM simulation and experiment on a developed device (combined microneedle), it was proven that the cooperative alternative motion of combined needles is much effective for reducing the necessary force for penetrating the skin. Moreover, a microneedle with sharp tip was realized, resistance force of which was much smaller than that of a commercial lancet needle.

以微创医疗为目的，提出了利用MEMS技术开发模拟蚊子鼻子的微针。用放大镜和高速摄像系统观察到蚊子喙在实验室透明薄皮上的穿透运动。通过观察证实了以下事实：(A)两个上颌骨插入人体皮肤组织，起到锚的作用。(B)将阴唇插入两个上颌之间的间隙。(A)和(B)的过程是循环重复的，而鼻子在物体内部进行得更深。考虑到蚊子鼻子的插入机理，通过动态有限元模拟和在研制的组合式微针装置上进行的实验，证明了组合针的协同交替运动对于减少穿透皮肤所需的力是非常有效的。此外，还实现了尖端尖端的微针，其阻力远小于商品的柳叶刀针头。

项目成果

エキシマレーザによる生分解性ポリマー製ニードルへのマイクロ穴加工

使用准分子激光在可生物降解聚合物针上钻微孔

• 发表时间: 2007
• 作者: 時永祥三;岸川善紀;泉 隼人
• 通讯作者: 泉 隼人

MEMS技術を援用したマイクロニードルの開発

利用MEMS技术开发微针

• 发表时间: 2010
• 作者: 林秀貞;増井忠幸;後藤正幸;青柳誠司
• 通讯作者: 青柳誠司

Three-Dimensionally Sharpened Silicon Microneedle with a Trench for Collecting Blood

三维锐化硅微针，带沟槽采血

• 发表时间: 2010
• 作者: H. Izumi;Y. Takaoki;C.H. Huang;M. Suzuki;T. Kanzaki;S. Aoyagi
• 通讯作者: S. Aoyagi

Realistic imitation of mosquito's proboscis: Electrochemically etched sharp and jagged needles and their cooperative inserting motion

• DOI: 10.1016/j.sna.2010.02.010
• 发表时间: 2011-01-01
• 期刊: SENSORS AND ACTUATORS A-PHYSICAL
• 影响因子: 4.6
• 作者: Izumi, Hayato;Suzuki, Masato;Kanzaki, Tsutomu
• 通讯作者: Kanzaki, Tsutomu

蚊の穿刺メカニズムの考察とマイクロニードルの開発

蚊虫穿刺机制的思考及微针的研制

• 发表时间: 2008
• 作者: 細谷直樹;草部浩一;泉 隼人
• 通讯作者: 泉 隼人