Studies Toward Total Synthesis of Polycyclic Natural Products with a Complex Chemical Structure and Distinctive Biological Properties

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Recently, there have been discovered an extremely small quantity of natural products with novel chemical structures and distinctive biological properties which have drawn much attention inside and outside the country, particularly, in relation to development of a new type of medicines. This research mainly aimed at chemical synthesis of the zoanthamine alkaloids that have exhibited potent biological and pharmacological activities. As a result, we achieved the first chemical syntheses of zoanthamine with powerful analgesic effects, and zoanthenol with potent antiplatelet activities on human platelet aggregation, followed the first total synthesis of norzoanthamine that has been expected as a promising candidate for an antiosteoporotic drug.