A study on lipid dynamics during pathogen infection

细胞脂质作为生物膜和信号分子的构建模块，因此是所有细胞的基本组成部分。在本研究中，我们分析了细胞脂质在丙型肝炎病毒和传染性朊病毒感染周期中的功能。我们发现人类丙型肝炎病毒的复制过程需要某些类型的磷酸肌醇。此外，我们发现使用新开发的感染性朊病毒传播测定系统，抑制鞘脂生物合成可显着抑制感染性朊病毒的细胞间传播。

Cellular lipids function as building blocks of biomembranes and signaling molecules thereby being fundamental components for all cells. In this study, we analyzed the function of cellular lipids for infection cycle of hepatitis C virus and infectious prion. We found that certain types of phosphoinositide were required for replication process of human hepatitis C virus. In addition, we found that the inhibition of sphingolipid biosynthesis substantially suppressed cell-to-cell transmission of infectious prion using newly developed infectious prion transmission assay system.