Molecular mechanism that induces cytokinesis

点击翻译按钮获取中文摘要

Actin was purified from fission yeast cells for the first time, and it was shown to polymerize into filaments that are indistinguishable from muscle actin filaments. The contractile ring actin filaments were visualized and their directionality was determined. Filaments were shown to shorten during contraction of the ring. We proposed that actin first polymerizes at one point in the division plane to both directions, and then the directionality was mixed in the ring prior to contraction. Using cultured fly cells we showed that myosin molecules in the cytoplasm accumulate at the division cortex during cytokinesis.