Bioactive compounds that regulate downstream migration of the sockeye salmon Oncorhynchus nerka

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Regulatory mechanisms by bioactive compounds of down-stream migration in the sockeye salmon (Oncorhynchus nerka) were investigated. Molecules involved in the regulation of the hypothalamo-pituitary-thyroid axis were selected as targets. cDNAs encoding thyrotropin-releaseing hormone (TRHa and TRHb), 4 subtypes of TRH receptor (TRHR1, TRHR2a, TRHR2b, and TRHR3), and deiodinase type II were cloned and the sites of expression were demonstrated by RT-PCR. These results indicate that the hypothalamo-pituitary-thyroid axis plays important roles in the regulation of down-stream migration of the sockeye salmon.