Impairment of memory and neurotoxic mechanism in male mice induced by exposure of domoic acid.

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To know the neurotoxic mechanism induced by domoic acid (DA ; amnesic shellfish poison), we administered DA to male mice by intraperitoneal injection. We found subacute impairment of contextual memory and delayed cued memory loss by using fear conditioning test. Although we never detect histopathological damages, i.e. neural death, neurofibrillary tangles, neural loss, we found the effects on synapse by immunohistochemical study in hippocampus of mice. Furthermore, we found the influences on axonal guidance signal pathway and synaptic function in hippocampus of mice by molecular analysis using percellome methods.