A Integrated Study of Pathological Significance of Cytosine Methylation of Non-CpG Island
A Integrated Study of Pathological Significance of Cytosine Methylation of Non-CpG Island
批准号:
19390100
负责人:
KITAZAWA Sohei
金额:
$6.49万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
Cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator. On the other hand, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we analyzed cytosine methylation status of the BAMBI gene promoter in bladder cancer and of the P16 in renal tumor of diabetic rats, and found that some of the cytosine methylation outside of the CpG-island contributes to the tumor development and progression.
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DOI:
10.1016/j.cdp.2008.05.005
发表时间:
2008-01-01
期刊:
CANCER DETECTION AND PREVENTION
影响因子:
--
作者:
[Niemhom, Sopaporn, Kitazawa, Sohei, Leopairat, Juvady]
通讯作者:
Leopairat, Juvady
DOI:
10.1002/jcb.21929
发表时间:
2008-12-01
期刊:
JOURNAL OF CELLULAR BIOCHEMISTRY
影响因子:
4
作者:
[Kitazawa, Riko, Mori, Kiyoshi, Kitazawa, Sohei]
通讯作者:
Kitazawa, Sohei
MeCP2 expression and promoter methylation of cyclin D1 gene are associated with cyclin D1 expression in developing rat epididymal duct.
Cyclin D1基因的MECP2表达和启动子甲基化与Cyclin d1表达在发育中的大鼠附子导管中有关。
DOI:
10.1267/ahc.08025
发表时间:
2008-10-29
期刊:
ACTA HISTOCHEMICA ET CYTOCHEMICA
影响因子:
2.4
作者:
[Darwanto, Agus, Kitazawa, Riko, Mori, Kiyoshi, Kondo, Takeshi, Kitazawa, Sohei]
通讯作者:
Kitazawa, Sohei
ラット酸化的ストレスモデルにおける腎腫瘍発生初期に生じるエピジェネティクス変化の解析
大鼠氧化应激模型中肾肿瘤发展早期发生的表观遗传变化分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[北澤荘平, 他]
通讯作者:
他
DOI:
10.1172/jci34090
发表时间:
2008-08-01
期刊:
JOURNAL OF CLINICAL INVESTIGATION
影响因子:
15.9
作者:
[Nishino, Naonobu, Tamori, Yoshikazu, Kasuga, Masato]
通讯作者:
Kasuga, Masato
共 25 条
Development of a new in situ technique demonstrating methyaled cytosine by iso-thermal DNA amplification method
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批准号:23659186
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$1.58万
-
财政年份:2011
-
负责人:KITAZAWA Sohei
-
依托单位:
DIVERSITY OF CANCER CELLS CAUSED BY CYTOSINE METHYLATION IN NON-CPG ISLAND
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批准号:16590278
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
-
财政年份:2004
-
负责人:KITAZAWA Sohei
-
依托单位:
ROLE OF RANKL IN OSTEOLYTIC BONE METASTASIS OF MALIGNANT TUMOR
-
批准号:13670217
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:2001
-
负责人:KITAZAWA Sohei
-
依托单位:
ANALYSIS OF THE GENE PROMOTERS OF HUMAN BONE MORPHOGENETIC PROTEINS
-
批准号:11670214
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:1999
-
负责人:KITAZAWA Sohei
-
依托单位:
ANALYSIS OF CYCLIN D1 GENE EXPRESSION BY METHYLATION OF CpG ISLAND LOCATED 5'-FLANKING REGION
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批准号:09670226
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:KITAZAWA Sohei
-
依托单位:
THE ROLE OF PTHrP AND INTEGRIN BETA3 SUBUNIT IN THE DEVELOPMENT OF SKELETAL METASTASES
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批准号:07670246
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1995
-
负责人:KITAZAWA Sohei
-
依托单位:
海外基金