Dioxin-induced imprinting of sexual immaturity and its mechanism
Dioxin-induced imprinting of sexual immaturity and its mechanism
批准号:
19390034
负责人:
YAMADA Hideyuki
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
The effects of maternal exposure to 2,3,7,8-tetra- chlorodibenzo- p-dioxin (TCDD), an environmental pollutant, on fetal maturation were studied in rats. The fetuses exposed to TCDD showed not only a reduction in the expression of gonadal proteins necessary for sex-steroid syntheses, but also impaired activity in sexual behaviors at adulthood. We also obtained evidence that above damages are due to a TCDD-produced reduction in fetal pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone.
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ダイオキシン母体曝露によるラット・性ホルモン合成系障害 : 周産期特異性と機構解析
母体二恶英暴露所致大鼠性激素合成系统紊乱:围产期特异性及机制分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[藤井美彩紀, 他4名]
通讯作者:
他4名
A reduction by TCDD in the expression of gonadotropin subunits : its perinatal age-specificity and the mechanism
TCDD 降低促性腺激素亚基的表达:其围产期年龄特异性及其机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takeda, T., et al.]
通讯作者:
et al.
ット脳下垂体luteinizing hormoneの刺激合成に対するダイオキシンの影響とその胎児特異性.
二恶英对垂体促黄体生成素合成的影响及其胎儿特异性。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[武田知起, 藤井美彩紀, 石井祐次, 石田卓巳, 山田英之]
通讯作者:
山田英之
ダイオキシン母体曝露による性行動障害のインプリンティングとその機構
母亲接触二恶英所致性行为障碍的印记及其机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[武田知起, 他6名]
通讯作者:
他6名
ダイオキシンによるラット脳下垂体luteinizing hormone合成障害と時期特異性
二恶英诱导的大鼠垂体黄体生成素合成和周期特异性受损
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[武田知起, 他4名]
通讯作者:
他4名
共 19 条
A new insight into the mechanism of dioxin toxicity: relevance of leukotrien B4 accumulation to toxcity and Yusho incident
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批准号:24659053
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2012
-
负责人:YAMADA Hideyuki
-
依托单位:
Mechanism underlying reproductive and developmental toxicity by dioxin : the role of a reduction in prolactin as an initial defect
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批准号:22659026
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$1.92万
-
财政年份:2010
-
负责人:YAMADA Hideyuki
-
依托单位:
Evidence for functional interaction between phase I and phase II drug metabolizing enzymes
-
批准号:14370765
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.66万
-
财政年份:2002
-
负责人:YAMADA Hideyuki
-
依托单位:
A novel approach for the mechanism of CYP2B induction: A study using mutant rats that lack response to the PB-mediated induction of CYP2B2 and the analyses of the gene structure and transcription factors
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批准号:12672173
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2000
-
负责人:YAMADA Hideyuki
-
依托单位:
Function of a new form of CYP2B and the inducer structure-inducing activity relationship
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批准号:07672365
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:YAMADA Hideyuki
-
依托单位:
Protein capable of binding to the upstream gene of the CYP2B subfamily P450
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批准号:05671829
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.34万
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财政年份:1993
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负责人:YAMADA Hideyuki
-
依托单位:
海外基金