Immuno-gene therapy for hepatocellular carcinoma : the arrangement of immunological surveillance system

肝细胞癌的免疫基因治疗：免疫监视系统的安排

• 批准号: 19390200
• 负责人: DEGUCHI Akihiro
• 金额: $ 11.73万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390200/
• 关键词: 肝癌; 肝硬変; サイトカイン; 樹状細胞

Expression of angiogenesis molecules in hepatocellular carcinomaAs compare with nontumorous tissue, enhanced FGF-・ or IL-8 expression was detected in hepatocellular carcinoma. In addition, FGF-・ or IL-8 was also increased in hepatocellular carcinoma cell lines.Expression of cytokine molecules in hepatocellular carcinomaMany cytokines enhanced in hepatocellular carcinoma is up-regulated, such as, activin, CD40, FGF, Glut, IL17 and FGF-・.Profiling of micro-RNA in hepatocellular carcinomaMicroRNA -527 was down-regulated in hepatocellular carcinoma.In addition, the target gene of microRNA-527 was glypican-3.

肝细胞癌组织中血管生成分子的表达与非肿瘤组织相比，肝细胞癌组织中成纤维细胞生长因子-·或IL-8的表达增强。肝细胞癌中多种细胞因子的表达上调，如激活素、CD40、成纤维细胞生长因子、GLUT、IL17和成纤维细胞生长因子-·等。

项目成果

Utility of pancreatic duct brushing for diagnosis of pancreatic carcinoma

• DOI: 10.1007/s00535-007-2071-7
• 发表时间: 2007-08-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Uchida, Naohito;Kamada, Hideki;Kuriyama, Shigeki
• 通讯作者: Kuriyama, Shigeki

A double filtering method for measuring the translational velocity of fluorescently stained cells

一种测量荧光染色细胞平移速度的双重过滤方法

• 发表时间: 2007
• 期刊: Appl Phys Lett 91
• 作者: Yasokawa T;Ishimaru I;Kuriyama S;Masaki T;Takegawa K;Tanaka N
• 通讯作者: Tanaka N

A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma

• DOI: 10.3748/wjg.14.2037
• 发表时间: 2008-04-01
• 期刊: WORLD JOURNAL OF GASTROENTEROLOGY
• 影响因子: 4.3
• 作者: Kurokohchi, Kazutaka;Watanabe, Seishiro;Kuriyama, Shigeki
• 通讯作者: Kuriyama, Shigeki

High concentration of lactic dehydrogenase in small volumes of ascites

少量腹水中乳酸脱氢酶浓度高

• 发表时间: 2010
• 期刊: J Gastrointestin Liver Dis. (1)
• 作者: Izuishi K;Masaki T;Suzuki Y
• 通讯作者: Suzuki Y

Education and imaging. Hepatobiliary and pancreatic:Isolated diaphragmatic metastasis from hepatocellular carcinoma

教育和成像。

• 发表时间: 2009
• 期刊: J Gastroenterol Hepatol 24
• 作者: Sano T;Izuishi K;Takebayashi R;Kushida Y;Masaki T;Suzuki Y
• 通讯作者: Suzuki Y