Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis
Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis
批准号:
19390199
负责人:
SAKAIDA Isao
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We have previously reported the effects of autologous bone marrow cell (BMC) infusion (ABMi) therapy in liver cirrhosis patients.The results showed that cell therapy using autologous BMC has the potential to become an effective treatment for patients with liver failure due to advanced liver cirrhosis.To analyze the cellular phenomena of involved in this process and the mechanism of dissolve in fibrosis, we checked the damaged liver using electron microscopy and estimated some kind of serum cytokines. We showed that G-CSF and IL1b is important and concerned about the proliferation of BMC in damage liver. We showed continuous high XBP1 and GRP78 expression might be essential for the survival and proliferation of BMC in liver damage environment.
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G-CSF is a candidate serum marker for ABMI therapy for liver cirrhosis patient
G-CSF是肝硬化患者ABMI治疗的候选血清标志物
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Mizunaga Y, Terai S, Yamamoto N, Sakaida I]
通讯作者:
Sakaida I
脾臓摘出術併用骨髄細胞投与による肝硬変の改善の検討
骨髓细胞注射联合脾切除术改善肝硬化的研究
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Fujiya M, Kohgo Y, 岩本拓也山本直樹寺井崇二坂井田功]
通讯作者:
岩本拓也山本直樹寺井崇二坂井田功
Importance of inhibitor DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation.
抑制剂 DNA 结合/分化 2 在肝星状细胞分化和增殖中的重要性。
DOI:
--
发表时间:
2007
期刊:
Hepatol Res. 37(8):
影响因子:
--
作者:
[SASAKI Makoto, Masataka HANEDA, ISHIDA Yoshiyuki, ISOBE Ken-ichi, Tajima K]
通讯作者:
Tajima K
DOI:
10.1016/j.bbrc.2008.10.154
发表时间:
2009-01-16
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ishigaki, Noriko, Yamamoto, Naold, Sakaida, Isao]
通讯作者:
Sakaida, Isao
骨髄幹細胞を用いた肝臓再生療法の開発の試み
尝试利用骨髓干细胞开发肝脏再生疗法
DOI:
--
发表时间:
2007
期刊:
日本再生医療学会雑誌 6(4)
影响因子:
--
作者:
[寺井 崇二, 他]
通讯作者:
他
共 66 条
The development research of liver regeneration therapy used bone marrow drived liver repaired cell
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批准号:20H03663
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2020
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负责人:SAKAIDA Isao
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依托单位:
The development of liver regeneration therapy with higher therapeutic effects on liver cirrhosis using a middle-large size liver cirrhosis model.
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批准号:17H04162
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.73万
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财政年份:2017
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负责人:SAKAIDA Isao
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依托单位:
Development of new gene transfer system for small fish
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批准号:22659148
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.04万
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财政年份:2010
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负责人:SAKAIDA Isao
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依托单位:
The development of cell therapy for liver fibrolysis and prevention of carcinogenesis using bone marrow cell transplantaion
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批准号:16590597
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
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负责人:SAKAIDA Isao
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依托单位:
Cross-talk of Ito(stellate) cell and preneoplastic and cancer cells of hepatocarcinogenesis
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批准号:11670507
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1999
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负责人:SAKAIDA Isao
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依托单位:
Carcinogenesis and Ito cell
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批准号:08670598
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:SAKAIDA Isao
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依托单位:
海外基金