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A study for restoration and regeneration of pancreatic exocrine function

A study for restoration and regeneration of pancreatic exocrine function
胰腺外分泌功能恢复与再生的研究
批准号:
19390203
负责人:
KYOKO Miyasaka
金额:
$11.81万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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中文摘要
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英文摘要
This study was designed to expect the recovery of pancreatic exocrine function from the damaged pancreas, not the regeneration from the pancreatic stem cells. Ki-ras-induced actin-interacting protein (KRAP) was originally identified in a human colon cancer cell, is conserved from fish to mammalian species. We found that the decrease and/or defect in KRAP expression resulted in pancreatic hypertrophy in mice. The level of KRAP mRNA in human cancer cell lines, in the tissues of pancreatic cancer and gallbladder cancer, and in normal pancreatic tissue did not differ to one another.
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Pancreatic hypertrophy in Ki-ras induced actin-interacting protein (KRAP) gene knockout mice.
Ki-ras 诱导肌动蛋白相互作用蛋白 (KRAP) 基因敲除小鼠的胰腺肥大。
DOI: --
发表时间: 2011
期刊: Pancreas
影响因子: 2.9
作者: [Miyasaka K, et al]
通讯作者: et al
Cholecystokinin 1 (A) receptor polymorphisms
胆囊收缩素 1 (A) 受体多态性
DOI: --
发表时间: 2007
期刊: Curr. Top. Med. Chem. 7
影响因子: --
作者: [Miyasaka, K., Takiguchi, S., Funakoshi, A.]
通讯作者: A.
DOI: 10.1371/journal.pone.0004240
发表时间: 2009
期刊: PLOS ONE
影响因子: 3.7
作者: [Fujimoto, Takahiro, Miyasaka, Kyoko, Koyanagi, Midori, Tsunoda, Toshiyuki, Baba, Iwai, Doi, Keiko, Ohta, Minoru, Kato, Norihiro, Sasazuki, Takehiko, Shirasawa, Senji]
通讯作者: Shirasawa, Senji
膵酵素とイオン分泌調節
胰酶和离子分泌调节
DOI: --
发表时间: 2008
期刊: 胆と膵 29
影响因子: --
作者: [Matsumoto, M., ら, 宮坂京子]
通讯作者: 宮坂京子
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