A study for restoration and regeneration of pancreatic exocrine function

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This study was designed to expect the recovery of pancreatic exocrine function from the damaged pancreas, not the regeneration from the pancreatic stem cells. Ki-ras-induced actin-interacting protein (KRAP) was originally identified in a human colon cancer cell, is conserved from fish to mammalian species. We found that the decrease and/or defect in KRAP expression resulted in pancreatic hypertrophy in mice. The level of KRAP mRNA in human cancer cell lines, in the tissues of pancreatic cancer and gallbladder cancer, and in normal pancreatic tissue did not differ to one another.