Molecular Target Therapy associated with EGFR mutation Analysis in Non-Small Cell Lung Cancer

非小细胞肺癌EGFR突变相关的分子靶向治疗分析

• 批准号: 19390367
• 负责人: FUJII Yoshitaka
• 金额: $ 9.82万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390367/
• 关键词: 呼吸器外科学; EGFR; 分子標的; 肺癌; R497K; エクソン20; 遺伝子増幅; ゲフィチニブ

肺癌におけるEGFR遺伝子変異の検索を進め、exon20の挿入変異はgefitinib抵抗例であった。Exon20、およびexon13のpolymorphismと臨床病理学的因子との相関を検討した。EGFR遺伝子増幅の検討はパラフィン切片を用いてFISHによる解析を行った。

Lung cancer EGFR gene mutation detection, exon20 and mutation detection Exon20, Exon13 and Polymorphic Factors Related to Clinical Pathology EGFR gene amplification and analysis by FISH

项目成果

Expression of excision repair cross-complementation group 1 and class III beta-tubulin predict survival after chemotherapy for completely resected non-small cell lung cancer

切除修复交叉互补组1和III类β微管蛋白的表达预测完全切除的非小细胞肺癌化疗后的生存率

• 发表时间: 2008
• 期刊: Lung Cancer 62(1)
• 作者: Okuda K;Sasaki H;Dumontet C;Kawano O;Yukiue H;Yokoyama T;Yano M;Fujii Y.
• 通讯作者: Fujii Y.

EGFR exon 20 insertion mutation in Japanese lung cancer

• DOI: 10.1016/j.lungcan.2007.06.024
• 发表时间: 2007-12-01
• 期刊: LUNG CANCER
• 影响因子: 5.3
• 作者: Sasaki, Hidefumi;Endo, Katsuhiko;Fujii, Yoshitaka
• 通讯作者: Fujii, Yoshitaka

Epidermal growth factor receptor gene mutation, amplification and protein expression in malignant pleural mesothelioma

• DOI: 10.1007/s00432-008-0384-4
• 发表时间: 2008-10-01
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Okuda, K.;Sasaki, H.;Fujii, Y.
• 通讯作者: Fujii, Y.

Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer

• DOI: 10.1007/s00432-007-0320-z
• 发表时间: 2008-05-01
• 期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
• 影响因子: 3.6
• 作者: Sasaki, Hidefumi;Endo, Katsuhiko;Fujii, Yoshitaka
• 通讯作者: Fujii, Yoshitaka

CCND1 messenger RNA expression is correlated with EGFR mutation status in lung cancer

CCND1信使RNA表达与肺癌中EGFR突变状态相关

• 发表时间: 2007
• 期刊: Clin Lung Cancer 8(8)
• 作者: Sasaki H;Okuda K;Endo K;Kawano O;Yukiue H;Yokoyama T;Yano M;Fujii Y
• 通讯作者: Fujii Y