Tyrosine kinase gene mutation and chemotherapy sensitivity in lung cancers.

点击翻译按钮获取中文摘要

ERCC1 C8092A and codon118C/T gene polymorphism statuses were evaluated for lung cancer patients who recieved adjuvant chemotherapy. We have investigated NRF2 gene mutation statuses in lung squamous cell carcinomas and compared with copy number, MRP3(multi-drug resistance-associated protein 3) expression and other clinico-pathological backgrounds. Novel KIF5B/RET translocation was found in lung cancer using a next-generation sequencing assay. KIF5B/RET transfected cells were sensitive to anti-RET drugs. We have developed fluorescence in situ hybridization(FISH) assay to detect KIF5B/RET transfusion gene.