Analysis of synovial sarcoma oncogene SYT-SSX for development of new therapy

点击翻译按钮获取中文摘要

The purpose of this study is to analyze the transforming mechanism of human synovial sarcoma-associated oncogene SYT-SSX and to establish the basic system for the development of new therapy. We originally proved that SYT-SSX is responsible oncogene for human synovial sarcoma, and in this study, we found that signalling adaptor protein Crk is involved in malignant feature of synovial sarcoma and one of the map kinase family protein as p38 plays an important role. Furthermore, SYT-SSX transgenic mice which develop synovial sarcoma and also SYT knockout mice were established in this study. The mice model of human synovial sarcoma should be expected to provide versatile effect for the evaluation of new therapeutic reagents.