Development of rapid and simultaneous diagnosis and therapy for musculoskeletal sarcomas using acridine orange excited by high-power flash light

使用高功率闪光灯激发吖啶橙快速同步诊断和治疗肌肉骨骼肉瘤的进展

• 批准号: 19390390
• 负责人: KUSUZAKI Katsuyuki
• 金额: $ 10.82万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390390/
• 关键词: アクリジンオレンジ; 光線力学的診断; 光線力学的治療法; 骨軟部腫瘍; ストロボ光; 安全性; 光線力学的療

To develop photodynamic diagnosis and photodynamic therapy using acridine orange excited by high-power flash light provided from xenon lamp in musculoskeletal sarcomas, we performed this study using mouse osteosarcoma model. Results showed that it was possible to brilliantly detect tumor localization through skin by PDD and to strongly inhibit tumor growth by PDT after intravenous AO injection followed by flash light illumination.

为探索利用氙灯高功率闪光灯激发的吖啶橙子光动力学诊断和光动力学治疗肌肉骨骼肉瘤的方法，我们采用小鼠骨肉瘤模型进行了这项研究。结果表明，这是可能的，通过皮肤的PDD和强烈抑制肿瘤生长后，静脉注射AO闪光灯照明的PDT通过出色的检测肿瘤定位。

项目成果

Novel Hyperthermia for MetastaticBone Tumors with Magnetic Materials

利用磁性材料治疗转移性骨肿瘤的新型热疗

• 发表时间: 2008
• 作者: Matsumine A;Kusuzaki K;Nakamura T,Niimi R;Nakazora S;Matsubara T,Satonaka H;Uchida A
• 通讯作者: Uchida A

Acridine orange could be an innovative anticancer agent under photon energy

吖啶橙可能是光子能量下的创新抗癌剂

• 发表时间: 2007
• 期刊: In Vivo 21
• 作者: Kusuzaki K;et. al.
• 通讯作者: et. al.

Extracorporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluorovisualization effect of acridine orange.

利用吖啶橙荧光可视化效应对小鼠软组织骨肉瘤进行体外光动力图像检测。

• 发表时间: 2006
• 期刊: Oncology 70(6)
• 作者: Satonaka H.;et al.
• 通讯作者: et al.

Extracorporeal Photodynamin Image Detection of Mouse Osteosarcoma in Soft Tissue Utilizing Fluorovisualizatiom Effect of Acridine Orange

利用吖啶橙荧光可视化作用进行体外光动力图像检测小鼠软组织骨肉瘤

• 发表时间: 2007
• 作者: Satonaka H;Kusuzaki K;et. al.
• 通讯作者: et. al.

Clinical Outcomes with the KYOCERA Physio Hinge Total Knee System Type III after the Resection of a bone and soft tissue tumor of the Distal Part of the Femur: from the Japanese Musculoskeletal Oncology Group 8th.

切除股骨远端骨和软组织肿瘤后使用 KYOCERA Physio Hinge 全膝关节系统 III 型的临床结果：来自日本肌肉骨骼肿瘤学第 8 组。

• 发表时间: 2010
• 作者: Matsumine A;Kusuzaki K;Sugita T;Yazawa Y;Isu K;Kawai A;Abe S;Yakushiji T;Ueda T;Uchida A
• 通讯作者: Uchida A