Activation of endogenous neural stem cells using choroid plexus epithelial cells aimed at a new therapy for central nervous system injury

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We demonstrated that the injection of cultured choroid plexus epithelial cells (CPECs) through cerebrospinal fluid (CSF) suppressed the extension of ischemic brain injury against a rat model of cerebral infarction. Anti-inflammatory, anti-apoptotic and anti-oxidative effects were involved in the neuroprotective mechanisms. It was considered that a variety of neurotrophic and/or growth factors were secreted from the CPECs into the CSF and prevented the ischemic brain injury. In addition, the CPECs transplantation activated neural stem cells, enhancing the neuronal differentiation. In vitro experiments suggested that hypoxic stress itself elicited the ability of CPECs to promote cerebral protection and regeneration.