Molecular mechanisms on differentiation or function of osteoblasts and osteoclasts by the Wnt/LRP signaling pathway

在这项研究中，我们证明了在骨形成和吸收过程中，Wnt和骨形态发生蛋白（BMP）两种细胞信号通路控制着成骨细胞和破骨细胞的分化和功能。这些Wnt和BMP信号调节骨保护素（OPG），也被称为破骨细胞生成抑制因子，可以抑制破骨细胞的产生。OPG表达的调控是通过两种转录途径介导的，如Wnt和BMP，这两种转录途径都涉及OPG启动子。我们还证明了由miRNA表达和BMP-2介导的成骨细胞分化在转录后水平下调miR-206的表达，BMP-2可以通过一种新机制调节miRNA的生物发生。

In this study, we demonstrated that two cellular signaling pathways of Wnt and bone morphogenetic protein (BMP) control both differentiation and function of osteoblasts and osteoclasts during processes of bone formation and resorption. These Wnt and BMP signaling regulates osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, which can inhibit the production of osteoclasts. The regulation of OPG expression is mediated through two transcription pathways such as Wnt and BMP that involve the OPG promoter. We also demonstrated that osteoblastic differentiation mediated by certain miRNA expression and BMP-2 down-regulates miR-206 expression at the post-transcriptional level and that BMP-2 could regulate miRNA biogenesis by a novel mechanism.