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Molecular mechanism of networking system between bone and hematopoietic cells via Wnt signaling pathway

Molecular mechanism of networking system between bone and hematopoietic cells via Wnt signaling pathway
Wnt信号通路骨与造血细胞网络系统的分子机制
批准号:
22390346
负责人:
TAMURA Masato
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010-04-01 至 2014-03-31

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中文摘要
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英文摘要
Canonical Wnt signaling molecule such as Wnt3a down-regulated CXCL12 expression in murine ST-2 cells. The culture supernatant from Wnt3a-ST2 cells also reduced migratory activity of bone marrow-derived cells and hematopoietic cell in a migration assay. Screostin which inhibits canonical Wnt signaling is identified as a signaling molecule from osteocytes to hematopoietic cell. The expression of neuropeptide Y Y1 receptor mRNA was induced by BMP2. These results raise the possibility that NPY acts in osteoblasts and osteocytes via an autocrine mechanism. From this study, functional crosstalk of regulation between bone and the other tissue.
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DOI: 10.1016/j.bbrc.2012.05.039
发表时间: 2012-06
期刊: Biochemical and biophysical research communications
影响因子: 3.1
作者: [E. Nemoto;Yukari Ebe;S. Kanaya;M. Tsuchiya;Takashi Nakamura;M. Tamura;H. Shimauchi]
通讯作者: E. Nemoto;Yukari Ebe;S. Kanaya;M. Tsuchiya;Takashi Nakamura;M. Tamura;H. Shimauchi
古典的Wntシグナルは骨髄ストローマ細胞のCXCL12発現を調節する
经典Wnt信号传导调节骨髓基质细胞中CXCL12的表达
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [神人友樹, 本山直世, 森田克也, 北山滋雄, 西村英紀, 兼松隆, 鶴田竜一・赤城裕一・中峠洋隆・寺邊健人・徳永 惇・西村友理・森周一郎・森田克也・北山友也・兼松 隆, 田村正人]
通讯作者: 田村正人
Canonical Wnt signaling regulates CXCL12 expression of stromal osteoblasts
经典 Wnt 信号传导调节基质成骨细胞的 CXCL12 表达
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Tamura M, Sato M]
通讯作者: Sato M
DOI: 10.3892/mmr.2013.1713
发表时间: 2013-12-01
期刊: MOLECULAR MEDICINE REPORTS
影响因子: 3.4
作者: [Tamura, Masato, Uyama, Maki, Sato, Mari]
通讯作者: Sato, Mari
7
    Regulation of osteoblastic differentiation by the ubiquitin-proteasome pathway and novel induction of bone formation
    • 批准号:
      23659865
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2011
    • 负责人:
      TAMURA Masato
    • 依托单位:
    Molecular mechanisms on differentiation or function of osteoblasts and osteoclasts by the Wnt/LRP signaling pathway
    • 批准号:
      19390469
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.06万
    • 财政年份:
      2007
    • 负责人:
      TAMURA Masato
    • 依托单位:
    The Studies of Ethno-history of Sakhalin Ainu in the period of Karafuto (20th century)
    • 批准号:
      18720250
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.52万
    • 财政年份:
      2006
    • 负责人:
      TAMURA Masato
    • 依托单位:
    STUDY OF BONE FORMATION SIGNALING IN WNT-LRP-DKK AND PROTEOSOME SYSTEM
    • 批准号:
      16390529
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.7万
    • 财政年份:
      2004
    • 负责人:
      TAMURA Masato
    • 依托单位:
    海外基金