Involvement of environmental iron in juvenile development of virus-related liver cancer in Myanmar

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Wet-lab courses were successfully held in Yangon and Nay-Pyi-Daw, in which totally 90 medical scientists joined to improve the state of the art. When the newly obtained HCC specimens were analyzed, only little accumulation of iron was found in HBV alone-positive specimens unlike HCV-positive ones. On the other hand, oxidative DNA damage was remarkable in the HBV specimens as well, indicating a possible difference in both viral-related liver carcinogenesis. Moreover, KGF seemed to be involved in the early onset of liver regeneration after partial hepatectomy in iron-overloaded rat model. The increase in both oxidative stress damage and expression of NF-κB found in the model may indicate a possible role of NF-κB in the acceleration of liver cell kinetics in iron-overloaded situations.