Pathogenesis of oral cancer due to chewing habits spread in Asia to East Africa

咀嚼习惯引起的口腔癌发病机制从亚洲传播到东非

• 批准号: 19406030
• 负责人: SAKU Takashi
• 金额: $ 10.65万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19406030/
• 关键词: 口腔がん; 噛みタバコ; 発症機構; 病理疫学; 分子病理学; 口腔粘膜下線維症; 分子病理疫学; 免疫組織化学; 細胞骨格; 細胞死; 増殖・浸潤; がん関連遺伝子; 粘膜下線維症; 細胞外基質; OSF; ISH

Since betel quid chewing in the south Asian area is the most representative causative factor of oral cancer, we surveyed oral cancer cases in Yemen, Jordan, Egypt, Sudan, Morocco, and Myanmar, where different sorts of chewing habits are performed. In those areas, chewing-related oral cancer was shown to be one of the most frequent cancers. Analyzing tissue specimens collected from there, we have established important histopathological diagnostic criteria for carcinoma in-situ and epithelial dysplasia both of which superficial carcinoma is comprised of. Their criteria were scientifically supported in multiple aspects by cell biology-based evidence.

由于咀嚼槟榔液在南亚地区是口腔癌最具代表性的致病因素，我们调查了也门、约旦、埃及、苏丹、摩洛哥和缅甸的口腔癌病例，这些国家有着不同的咀嚼习惯。在这些地区，咀嚼相关的口腔癌被证明是最常见的癌症之一。分析从那里收集的组织标本，我们建立了重要的原位癌和上皮异常增生的组织病理学诊断标准，这两种类型的浅表性癌均由浅表性癌组成。他们的标准在多方面得到了基于细胞生物学的证据的科学支持。

项目成果

正角化型口腔異型上皮における構成細胞のテロメア長と染色体不安定性についてQ-FISH法による解析

Q-FISH法分析口腔适形非典型上皮细胞的端粒长度和染色体不稳定性

• 发表时间: 2010
• 作者: 相田順子;田久保海誉
• 通讯作者: 田久保海誉

Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology

• DOI: 10.1111/j.1365-2559.2010.03712.x
• 发表时间: 2010-12
• 期刊: Histopathology
• 影响因子: 6.4
• 作者: M. Tsuneki;M. Yamazaki;Jun Cheng;S. Maruyama;Takanori Kobayashi;T. Saku

Twin-pair rete ridge analysis : a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa.

双对网脊分析：一种计算机辅助方法，用于促进口腔粘膜上皮发育不良和原位癌之间客观的组织病理学区分。

• 发表时间: 2010
• 期刊: Oral Medicine & Pathology 14(3)
• 作者: Sami MM;Saito M;Muramatsu S;Mikami T;Al-Eryani K;Sawair FA;Eid RA;Cheng J;Kikuchi H;Saku T
• 通讯作者: Saku T

Differential diagnosis of intraductal papilloma and pleomorphic adenoma of salivary gland

导管内乳头状瘤与唾液腺多形性腺瘤的鉴别诊断

• 发表时间: 2010
• 作者: Masaru Kada;Harumichi Nishimura;Tomoyuki Yamakami;Tomoyuki Yamakami;Ahsan MS;長谷川真弓;Tomoyuki Yamakami;T. Yamakami;丸山智;Francois Le Gall;Ahsan MS
• 通讯作者: Ahsan MS

Recurrence of leukoplakias as evidence for malignancy : histopathological varieties of oral carcinoma in-situ.

白斑复发作为恶性肿瘤的证据：口腔原位癌的组织病理学变化。

• 发表时间: 2008
• 作者: 長谷川真弓,丸山智,程〓;齊藤力,朔敬;Saku T.;Al-Eryani K.;Saku T;Tsuneki M;Al-Eryani K;丸山智;丸山智;常木雅之;Ahsan S;小林孝憲;阿部逹也;Al-Eryani K;Alvarado C;常木雅之;長谷川真弓;朔敬
• 通讯作者: 朔敬