Pathogenesis of oral cancer due to chewing habits spread in Asia to East Africa

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Since betel quid chewing in the south Asian area is the most representative causative factor of oral cancer, we surveyed oral cancer cases in Yemen, Jordan, Egypt, Sudan, Morocco, and Myanmar, where different sorts of chewing habits are performed. In those areas, chewing-related oral cancer was shown to be one of the most frequent cancers. Analyzing tissue specimens collected from there, we have established important histopathological diagnostic criteria for carcinoma in-situ and epithelial dysplasia both of which superficial carcinoma is comprised of. Their criteria were scientifically supported in multiple aspects by cell biology-based evidence.