Bioinformatics analysis of transition metal-binding proteins

过渡金属结合蛋白的生物信息学分析

• 批准号: 19500255
• 负责人: NAKAMURA Kensuke
• 金额: $ 2.91万
• 依托单位: Nara Institute of Science and Technology (2008-2009)Japan Atomic Energy Agency (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500255/
• 关键词: 金属タンパク質; ゲノム; 生命情報学; 酵素; 進化; メタローム; 金属結合タンパク質; メタロミクス; 分子進化; 遷移金属イオン; 配列解析; データベース; タンパク質; 遷移金属; 構造ゲノミクス

Some of the transition metal ions such as iron, copper and zinc are known to be essential for life. Most of these transition metal ions in biological systems are functioning as complexes with specific metal binding proteins. The emergence of the terms such as metallome and metallomics, is indicating the increasing interest toward these metal binding proteins. Under such a circumstance, where a useful public bioinformatics resource for metal binding proteins is being desired, we have developed a new database system called MetalMine, which includes structural information of metal binding sites in an organized fashon. MetalMine is the largest database concerning metal binding proteins, in terms of the number of metal binding sites included, and it would serve as a quite useful resource for the functional analysis of proteins.

一些过渡金属离子，如铁、铜和锌，是生命所必需的。这些过渡金属离子在生物系统中大多与特定的金属结合蛋白起配合物的作用。金属组学和金属组学等术语的出现表明人们对这些金属结合蛋白的兴趣越来越大。在这种情况下，我们需要一个有用的公共金属结合蛋白生物信息学资源，我们开发了一个新的数据库系统，称为MetalMine，它包括金属结合位点的结构信息，以有组织的方式。MetalMine是关于金属结合蛋白的最大的数据库，包含了大量的金属结合位点，它将为蛋白质的功能分析提供非常有用的资源。

项目成果

Metallome in coordination with Metabolome

Metallome 与 Metabolome 协调

• 发表时间: 2010
• 作者: K. Nakamura;A. Hirai;H. Takahashi;S. Kanaya
• 通讯作者: S. Kanaya

BAAQ:An Infrastructure for Application Intergration and Knowledge Discovery in Bioinformatics

BAAQ：生物信息学应用集成和知识发现的基础设施

• 发表时间: 2007
• 期刊: IEEE Transaction on Information Technology in Biomedicine 11
• 作者: Gong Xiujun;K. Nakamura;et. al.
• 通讯作者: et. al.

A synthetic study on gymnastatins F and Q: the tandem Michael and aldol reaction approach

• DOI: 10.1016/j.tetlet.2009.01.156
• 发表时间: 2009-07-01
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Murayama, Kyoko;Tanabe, Takamasa;Nishiyama, Shigeru
• 通讯作者: Nishiyama, Shigeru

Anapproach to peak detection in GC-MS chromatograms and application of KNApSAcK database in prediction of candidate metabolites

GC-MS 色谱峰检测方法及 KNApSAcK 数据库在候选代谢物预测中的应用

• 发表时间: 2009
• 期刊: Plant Biotechnology vol.26
• 作者: T. Oishi;(他16名12番目)
• 通讯作者: (他16名12番目)

MetalMine : a database of functional metal-binding sites in proteins

MetalMine：蛋白质中功能性金属结合位点的数据库

• 发表时间: 2009
• 期刊: Plant Biotechnology 26
• 作者: K.Nakamura;A.Hirai;Md.Altaf-Ul-Amin;H.Takahashi
• 通讯作者: H.Takahashi