Isolation of repair-deficient mutants for clustered DNA damage

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We have found that the position and types of lesions within the clustered DNA damage are strongly relevant to the biological consequences of clustered DNA damage. We have also demonstrated that the clustering of DNA damage is strongly related to the ionizing density of the radiation. These results have important implications for both the understanding of underlying mechanisms of radiation action to cells and the practical application of ionizing radiation (ie.assessment of low dose risk, improvement of radiation therapy etc.).