The structural domains of Chondromodulin-I, an angiogenesis inhibitor, and their contribution to its bioactivity
The structural domains of Chondromodulin-I, an angiogenesis inhibitor, and their contribution to its bioactivity
批准号:
19510217
负责人:
HIRAKI Yuji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
Chondromodulin-Iは無血管軟骨特異的に発現し、その細胞外基質に蓄積する生理的血管新生抑制因子である。血管新生促進因子と比較して、血管新生抑制因子の血管内皮細胞に対する作用機序は、十分に解明されていない。そこで、本研究では、まず、無血清条件下にヒトChondromodulin-Iの大量発現を確立すると同時に迅速簡便精製を行い、高活性の組換え体を調製する。さらに、欠失を含む種々の変異組換えChondromodulin-Iタンパク質を発現させる事により、Chondromoduin-Iの分子特性と活性ドメインの構造を明らかにすることに成功した。
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DOI:
--
发表时间:
2007
期刊:
Design 13
影响因子:
--
作者:
[C. Shukunami, Y. Hiraki Chondromodulin-I and Tenomodulin]
通讯作者:
Y. Hiraki Chondromodulin-I and Tenomodulin
軟骨形成・維持とECM環境
软骨形成/维持和 ECM 环境
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[開祐司, 開祐司]
通讯作者:
開祐司
A potential role of decidual chondromodulin-I in the control of cell migration and invasion of trophoblast giant cells
蜕膜软骨调节蛋白-I 在控制滋养层巨细胞的细胞迁移和侵袭中的潜在作用
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[S. Miura, C. Shukunami, Y. Nishizaki, Y. Hiraki]
通讯作者:
Y. Hiraki
DOI:
10.1007/s00441-007-0570-8
发表时间:
2008-04-01
期刊:
CELL AND TISSUE RESEARCH
影响因子:
3.6
作者:
[Shukunami, Chisa, Takimoto, Aki, Hiraki, Yuji]
通讯作者:
Hiraki, Yuji
DOI:
10.1007/s00774-009-0038-x
发表时间:
2009-05-01
期刊:
JOURNAL OF BONE AND MINERAL METABOLISM
影响因子:
3.3
作者:
[Anraku, Yoshihisa, Mizuta, Hiroshi, Hiraki, Yuji]
通讯作者:
Hiraki, Yuji
共 9 条
The structural determination and anti-angiogenic activity of a Chondromodulin-I subtype that lacks the N-terminal domain.
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批准号:21510224
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2009
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负责人:HIRAKI Yuji
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依托单位:
Molecular basis of anti-angiogenic barriers in mesenchymal tissues
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批准号:17014046
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$29.06万
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财政年份:2005
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负责人:HIRAKI Yuji
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依托单位:
Cloning of Mouse Chondromodulin-I cDNA and Localization of the Gene Transcripts
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批准号:09671892
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:1997
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负责人:HIRAKI Yuji
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依托单位:
Purification of Osteoclast Differentiation Factor produced by Epiphyseal Cartilage
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批准号:07672014
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:HIRAKI Yuji
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依托单位:
Inhibitory action mechanism of cartilage-specific functional martix/chondromodulin-I on growth of vascular endothelial cells.
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批准号:05837010
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.15万
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财政年份:1993
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负责人:HIRAKI Yuji
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依托单位:
Molecular cloning of a cartilage-derived growth modulating factor, chondromodulin-I(ChM-I) and functional expression of ChM-I cDNA
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批准号:03680148
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1991
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负责人:HIRAKI Yuji
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依托单位:
Isolation and Identification of Cartilage-derived Factor (CDF) and its Precursor.
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批准号:01580163
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1989
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负责人:HIRAKI Yuji
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依托单位:
海外基金