Development and Application of Novel Environmentally Friendly Asymmetric Organocatalysts for the Asymmetric Chemical Modification of Nitrogen Heterocycles

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Since many low molecular weight organic compounds are naturally decomposed by microorganisms and such, organic catalysts are considered environmentally friendly. In this study, a series of novel optically active nitrogen containing heterocycles were synthesized from the amino acid phenylalanine and application to the Michael addition reaction, one of the most well known carbon-carbon bond forming reactions, showed the reaction to be highly enantioselective. In addition, we have succeeded in developing a method of preparing furans, which are highly versatile as synthetic intermediates, from acyclic compounds without the use of catalysts.