Roles of Tbx22 during early stage of secondary palate development.

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In this project, we focused on the developmental process of the secondary palate and tongue in chick embryo, and analyzed the expression and function of Tbx22, which is involved in X-linked cleft palate and ankyloglossia in human. Expression of Tbx22 is observed in the oral side of the maxillary process where the palatal shelf is emerged later, and in the bottom region of the tongue. The expression is regulated by BMP signaling. Misexpression of Tbx22 suppressed proliferation of cells in the facial processes, and inhibited osteogenesis of the cells, suggesting the suppressive role of Tbx22 on the formation of the secondary palate and tongue.