Fundamental researches for pathologic elucidation and antemortem diagnosis in the cerebrospinal degenerative diseases of animals.

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The research revealed the clinical and pathological features of cerebellar cortical abiotrophy (CCA) in Papillon dogs, neuroaxonal dystrophy (NAD) in Papillon and Chihuahua dogs, and ceroid-lipofuscinosis in Chihuahua dogs. By antemortem image analysis, all these degenerative canine diseases were characterized by moderate to severe cerebellar atrophy. Pathologically, the pathway of neuronal death was differ among these diseases ; apoptosis in CCA, inflammatory reaction associated ceroid-lipofuscin deposits in NCL, and some other injury associated synaptic processes in NAD, are suspected as major role of the pathologic events, respectively.