The role of autoimmune response and pathogenesis of neurological diseases in animals

在4年的科研资助期间，对犬炎性神经元疾病有了一些新的证据。我们先前的研究表明，在犬坏死性脑膜脑炎(NME)和肉芽肿性脑膜脑炎(GME)中存在抗星形胶质细胞的自身抗体。这些抗体在这些犬病中的重要性已经通过与其他实验室的确证研究得到了证实(J.Vet。地中海医院。SCI。66：295-297,2004)。在犬NME和GME的炎症过程中，小胶质细胞和/或巨噬细胞表达MHC-II和T淋巴细胞的浸润被认为是炎症过程中的重要事件。此外，在NME患者的脑内，星形胶质细胞及其突起内有明显的IgG和C3沉积，提示抗体依赖的细胞损伤(J.Vet。地中海医院。SCI。65：1233-1239,2003)。所有这些结果表明，犬非酒精性胃炎和胃肠炎是自身抗体相关的炎性…。更多的保守党疾病。犬NME中抗体和补体相关的细胞损伤和GME中T细胞介导的扩张型变态反应可能分别在这些疾病的发病机制中起重要作用。此外，还研究了犬神经节细胞增殖性神经炎(感觉神经病)的发病机制。结果表明T细胞介导的免疫反应的重要性，常规剂量的激素处方似乎难以获得完全的排泄。用病犬血清进行间接免疫荧光试验，未检测到针对犬神经组织的自身抗体。提示T细胞介导的免疫反应在犬多发性神经根炎(浣熊麻痹)的发病机制中起主要作用。这些结果的发表过程正在进行中。除了猫和狗的炎症性疾病外，已经收集了几种神经疾病，其中一些在这项拨款的支持下发表在科学期刊上。较少

During the period of Grant-in-Aid for Scientific Research for 4 years, several new evidences concerning inflammatory neuronal disorders in dogs have been obtained. Our previous research has been revealed the presence of the autoantibody against astrocytes in canine necrotizing meningoencephalitis (NME) and granulomatous meningoencephalitis (GME). The significance of the antibodies in these canine diseases has been confirmed by corroborative research with other laboratory (J. Vet. Med. Sci. 66: 295-297, 2004). In the inflammatory process of canine NME and GME, the expression of MHC class II by microglia and/or macrophages and infiltration of T lymphocytes were considered to be the important events. Moreover, in the brain with NME, there was prominent deposit of IgG and C3 within astrocytes and their processes, suggesting the antibody dependent cellular injury (J. Vet. Med. Sci. 65: 1233-1239, 2003). All these findings indicate that canine NME and GME are autoantibody-associated inflamma … More tory diseases. Antibody and complement-associated cellular injury in canine NME and T-cell mediated dilated type allergy response in GME might be important for the pathogenesis of these diseases, respectively.Besides, the pathogenesis of canine ganglioradiculoneuritis (sensory neuropathy) has been also investigated. The results indicated the importance of T cell mediated immune reaction and the prescription by common dose of corticosteroid seemed to be difficult to obtain complete emission. By indirect immunofluorescence assay using sera from affected dogs, no autoantibodies against canine nerve tissues were detected. The results might indicate that T cell-mediated immune response is most likely to play the major role in the pathogenesis of canine sensory neuropathy is suggested in idiopathic canine polyradiculitis (Coon hunt paralysis). Publication process for these results is in progress.Several neurological diseases other than inflammatory disorders in dogs and cats have been collected and some of them were reported in scientific journals by the supp ort of this grant. Less