Chemical syntheses of oligosaccharides to elucidate host-parasite interactions

近年来，哺乳动物组织中糖蛋白和鞘糖脂的寡糖残基因其具有多种生物识别功能而被广泛研究。相比之下，很少有时间致力于从哺乳动物的聚糖显着不同的无脊椎动物的寡糖的结构。由于聚糖结构的这些差异，我们一直对无脊椎动物寡糖的结构和生物活性之间的关系感兴趣，并在我们的持续研究中阐明宿主-寄生虫相互作用的机制。本论文以蠕虫、泡球蚴、猪蛔虫、曼氏血吸虫和接合菌中的冬季毛霉为原料，进行了寡糖的合成，得到了二十多种目标寡糖。

The oligosaccharide residues of glycoprotein and glycosphingolipids in mammalian tissues have been extensively studied for various biological recognition in recent years. In contrast, much less time has been devoted to structures of oligosaccharides from invertebrates that differ significantly from mammalian glycans. Due to these differences in the glycan structure we have been interested in the relationships between the structure and biological activity of oligosaccharides from invertebrate species, and in our continuing studies to elucidate the mechanism of host-parasite interaction. We carried out the synthesis of oligosaccharides from the helminth, Echinococcus multilocularis, Ascaris suum, Schistosoma mansoni and Zygomycetes species Mucor hiemalis, and got target oligosaccharides more than twenty kinds.