Study on metabolic control and intracellular transport of phospholipids

点击翻译按钮获取中文摘要

Metabolic control and intracellular transport of phospholipids are essential events for membrane biogenesis in eukaryotes. The synthesis of phosphatidylserine (PS), one of major phospholipids in mammalian cells, occurs in the endoplasmic reticulum, and many of nascent PS are transported into mitochondria. In this study, to elucidate regulatory mechanisms of PS biosynthesis we purified human PS synthase 1 and 2. Furthermore, we showed that a mitochondrial protein (designated as mitocoil), which is suggested to be involved in PS transport into mitochondria, regulates mitochondrial morphology