The mechanism of diabetic the neuropathic pain : Approach to novel drugs

(1)因此，在本研究中，我们详细研究了糖尿病神经病理性疼痛的机制。特别是，我们展示了脊髓毒蕈碱受体和ATP受体如何参与神经病理性疼痛。此外，预先给予小胶质细胞抑制剂米诺环素可抑制异常性疼痛。(2)过氧化物酶体增殖物激活受体γ（PPARgamma）在瘦素缺乏（ob/ob）小鼠肝脏中被诱导，并且对肝脂肪变性的发展至关重要。我们认为肥胖症小鼠肝脏中的脂肪特异性蛋白27（Fsp 27）是PPAR γ的直接靶基因，并可升高肝脏甘油三酯水平。

(1) In this study, therefore, we examined the mechanism of diabetic neuropathic pain in detail. Especially, we demonstrated how the spinal muscarinic receptors and the ATP receptors involve in neuropathic pain. In addition, pre-administrations of microglia inhibitor minocycline inhibited the allodynia. (2) Peroxisome proliferator-activated receptor gamma (PPARgamma) is induced in leptin-deficient (ob/ob) mouse liver and is critical for the development of hepatic steatosis. We exanimed that fat-specific protein 27 (Fsp27) in ob/ob liver is a direct target gene of PPARgamma and can elevate hepatic triglyceride levels.