Identification of a receptor for the carcinogenic factor secreted from H.pylori, and analysis of its membrane trafficking mechanism

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Tumor necrosis factor-α inducing protein (Tipα) is a unique carcinogenic factor released from H.pylori. We found that nucleolin acts as a receptor for Tipα, that it shuttles Tipα from the cell surface to nuclei, resulting in TNF-α gene expression. Although nucleolin is a well-known nucleolar protein, nucleolin is also present on the cell surface of gastric cancer cells. So cells with nucleolin on the surface are thought to be a highly susceptible to Tipα for development of gastric cancer. These results indicate the significance of Tipα interaction with nucleolin as a new carcinogenic mechanism in the stomach.