Identification of a receptor for the carcinogenic factor secreted from H.pylori, and analysis of its membrane trafficking mechanism

幽门螺杆菌致癌因子受体的鉴定及其膜运输机制分析

• 批准号: 19590325
• 负责人: SUGANUMA Masami
• 金额: $ 2.91万
• 依托单位: Research Institute for Clinical Oncology, Saitama Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590325/
• 关键词: NF-κB; ピロリ菌; TNF-α inducing protein; TNF-α; ヌクレオリン; 発がんプロモーション; 炎症; 胃がん; Tipαレセプター; 発がん促進; DNA 結合; 発がん足進; Biacore

Tumor necrosis factor-α inducing protein (Tipα) is a unique carcinogenic factor released from H.pylori. We found that nucleolin acts as a receptor for Tipα, that it shuttles Tipα from the cell surface to nuclei, resulting in TNF-α gene expression. Although nucleolin is a well-known nucleolar protein, nucleolin is also present on the cell surface of gastric cancer cells. So cells with nucleolin on the surface are thought to be a highly susceptible to Tipα for development of gastric cancer. These results indicate the significance of Tipα interaction with nucleolin as a new carcinogenic mechanism in the stomach.

肿瘤坏死因子-α诱导蛋白（Tumor necrosis factor-α inducing protein，Tipα）是幽门螺杆菌分泌的一种独特的致癌因子。我们发现核仁素作为Tipα的受体，它将Tipα从细胞表面运送到细胞核，导致TNF-α基因表达。虽然核仁素是一种众所周知的核仁蛋白，但核仁素也存在于胃癌细胞的细胞表面。因此，表面有核仁素的细胞被认为是对Tipα高度敏感的胃癌细胞。提示Tipα与核仁素的相互作用可能是胃内一种新的致癌机制。

项目成果

Synergistic effects of multiple treatments, and both DNA and RNA direct bindings on, green tea catechins

• DOI: 10.1002/mc.20332
• 发表时间: 2007-08-01
• 期刊: MOLECULAR CARCINOGENESIS
• 影响因子: 4.6
• 作者: Kuzuhara, Takashi;Tanabe, Akitoshi;Fujiki, Hirota
• 通讯作者: Fujiki, Hirota

目Neocomplanines A and B, a complanine family isolated from the marine fireworm.

Neocomplanines A 和 B，从海洋火虫中分离出来的一个科。

• 发表时间: 2010
• 期刊: J. Nat. Prod. 73
• 作者: Nakamura;K.;Suganuma;M.;et al.;他4名5番目
• 通讯作者: 他4名5番目

Significance of Tipα, a unique carcinogenic factor of H. pylori in gastric cancer development.

幽门螺杆菌独特的致癌因子Tipα在胃癌发展中的意义。

• 发表时间: 2007
• 作者: Suganuma;M.
• 通讯作者: M.

Nucleolin on the Cell Surface as a New Molecular Target for Gastric Cancer Treatment

• DOI: 10.1248/bpb.33.796
• 发表时间: 2010-05-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Watanabe, Tatsuro;Hirano, Kazuya;Suganuma, Masami
• 通讯作者: Suganuma, Masami

Neocomplanines A and B, a Complanine Family Isolated from the Marine Fireworm

• DOI: 10.1021/np900694j
• 发表时间: 2010-03-01
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Nakamura, Kazuhiko;Tachikawa, Yu;Uemura, Daisuke
• 通讯作者: Uemura, Daisuke