Basic research for development of CTL-inducible vaccine against West Nile virus using recombinant E protein

点击翻译按钮获取中文摘要

West Nile virus (WNV) is the human-infectious virus, which sometimes causes lethal encephalitis/meningitis, and the vaccine for human use has not been developed yet. Based on the findings concerning its relative viruses, it is anticipated that the envelope (E) protein should induce protective immunity. In the present study, we have established several recombinant WNV E protein expression systems and the CTL target cells in order to develop the recombinant component vaccine against WNV infection, which induces not only neutralizing antibody but also CTL, using recombinant WNV E protein combined with cross-presentation inducing adjuvant.