Prospective cohort study to reduce the incidence of infant asthma

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The cumulative incidence in the health check-up at 18 months of age was 5.4% for physician-diagnosed asthma, 6.3% for atopic eczema, 13.7% for food allergy, and 1.1% for hay fever. The cumulative incidence in the health check-up at 42 months of age was 10.1% for physician-diagnosed asthma, 11.2% for atopic eczema, 12.3% for food allergy, and 3.2% for hay fever. Maternal smoking during pregnancy is positively associated with the cumulative incidence of physician-diagnosed asthma in the health check-up at 18 months of age. Compared with nonsmokers who were both mother and household, odds ratio for asthma was higher in smokers who were both mother and household.