The Role of Adrenaline in Neurally Mediated Syncope

肾上腺素在神经介导性晕厥中的作用

• 批准号: 22590797
• 负责人: SATO Kyoko
• 金额: $ 2.83万
• 依托单位: Tokyo Women's Medical University (2011-2012)Tokai University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590797/
• 关键词: 神経調節性失神; アドレナリン; 自律神経; アドレナリンレセプター; アドレナリン受容体; 遺伝子多型性

yncope is a common problem associated with a poor quality of life. A majority of patients suffer from neurally mediated syncope (NMS), which is poorly understood in its pathophysiology. We evaluated cardiovascular autonomic functions as well as genetic polymorphisms of the α2B adrenoceptors (α2B-AR) predisposed to NMS patients (n=8, age 39±11 year, BMI 24±4 kg/m2) and healthy subjects (n=10, age 30±7 year, BMI 25±3 kg/m2). The standard autonomic function test (AFT) and head-up tilt (HUT) test were performed on each subject. Plasma catecholamines (CATs), renin, and aldosterone were measured after 30 minutes supine and at the end of the HUT. Twenty-four-hour urine collections were used to measure sodium and CATs excretion. A polymorphism of glutamic acid (Glu) repeats (Glu 12 or Glu 9, amino acids residues 301-303) present in the α2B AR was identified. We had three Glu 12/12, twelve Glu 12/9, and two Glu 9/9 subjects among the NMS patients and healthy controls; all of the NMS patients showed Glu 12/9. Syncopal subjects had Glu12/12 or Glu12/9 whereas subjects who had Glu9/9 did not have orthostatic symptom (OS). Therefore, we will investigate the possibility of this polymorphism as a marker of human vasomotor responses during orthostatic stress using subjects with and without NMS

YNCOPE是与生活质量差有关的常见问题。大多数患者患有中性介导的晕厥（NMS），其病理生理学对此知之甚少。我们评估了患有NMS患者（n = 8，39±11岁，BMI 24±4 kg/m2）和健康的受试者（n = 10，n = 10，n = 10，年龄30±7 peal year，n = 10±7 peal ealtim，n = 8年，n = 8，年龄39±11岁，年龄39±11岁，年龄为39±11岁，α2B-AR）的心血管自主功能以及遗传多态性（α2B-AR）。对每个受试者进行了标准的自主功能测试（AFT）和头部倾斜（HUT）测试。在30分钟后和小屋结束时测量了血浆儿茶酚胺（CAT），肾素和醛固酮。 24小时的尿液收集用于测量钠和猫极端。鉴定了谷氨酸重复（GLU 12或GLU 9，氨基酸残留301-303）的多态性。在NMS患者和健康对照组中，我们有三个GLU 12/12，十二GLU 12/9，还有两个GLU 9/9受试者。所有NMS患者均显示GLU 12/9。促鼻腔受试者具有GLU12/12或GLU12/9，而患有GLU9/9的受试者没有正常症状（OS）。因此，我们将研究这种多态性作为人体血管舒缩反应的可能性，使用或不带有NMS的受试者在体位压力期间。

项目成果

The Application for Genetic Evaluation of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope

人类肾上腺素受体多态性在神经介导性晕厥遗传评价中的应用

• 发表时间: 2012
• 作者: Kyoko Sato;Tomoyoshi Komiyama;Hiroyuki Kobayashi;Kuniaki Otsuka
• 通讯作者: Kuniaki Otsuka

Possible Association of Human Adrenoceptors Polymorphism in Neurally Mediated Syncope

人类肾上腺素受体多态性与神经介导性晕厥的可能关联

• 发表时间: 2011
• 作者: Kyoko Sato;Tomoyoshi Komiyama;Hiroshi Kamiguchi;Ayako Mikami;Hiroyuki Kobayashi;Kuniaki Otsuka
• 通讯作者: Kuniaki Otsuka