Analysis of esophagopharyngeal reflux using 24-hr ambulatory pharyngoesophageal impedance and pH monitoring

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We studied patients with chronic cough who responded to full-dose PPI therapy, in whom 24-hr pharyngoesophageal impedance and pH monitoring was performed. Most patients with chronic cough responding to PPIs had minor acidic gas reflux and/or swallow-induced weakly acidic and/or acidic reflux in the pharynx. A direct effect of acidic mist or acidic liquid refluxing into the pharynx was suggested to be the cause of their chronic cough. In some patients, symptoms may arise indirectly from gastroesophageal reflux via a vago-vagal reflex.