A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis

在三磷酸腺苷结合盒转运体(ABC)G1启动子中发现了一种新的-257T&GT；G单核苷酸多态性(SNP)。-257T&gT；G SNP体外转录活性降低。在对Abcg1-257T&GT；G SNP的临床分析中，虽然Abcg1与血浆胆固醇水平无关，但已发现Abcg1对缺血性心脏病患者的脂蛋白组成如高密度脂蛋白产生了影响。这是一项新的发现，表明Abcg1有助于保护动脉粥样硬化的进展。

A novel -257T>G single nucleotide polymorphism (SNP) was found in ATP-Binding Cassette Transporter (ABC) G1 promoter. The -257T>G SNP had a reduced transcriptional activity of ABCG1 invitro. In the clinical analysis of ABCG1 -257T>G SNP, although ABCG1 was not related with plasma cholesterol levels, it was shown that ABCG1 had affected to a lipoprotein composition such as HDL prticle in patients with ischemic heart disease. This is a new finding to show that ABCG1 contributes to protect a progression of atherosclerosis.