A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis

膜胆固醇转运蛋白的新功能和动脉粥样硬化的治疗策略

• 批准号: 19590874
• 负责人: UEHARA Yoshinari
• 金额: $ 2.83万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590874/
• 关键词: 脂質; 循環器・高血圧; 高比重リポ蛋白; 発現制御; 遺伝子多型; リポ蛋白; アポリポ蛋白; 臨床; 遺伝子

A novel -257T>G single nucleotide polymorphism (SNP) was found in ATP-Binding Cassette Transporter (ABC) G1 promoter. The -257T>G SNP had a reduced transcriptional activity of ABCG1 invitro. In the clinical analysis of ABCG1 -257T>G SNP, although ABCG1 was not related with plasma cholesterol levels, it was shown that ABCG1 had affected to a lipoprotein composition such as HDL prticle in patients with ischemic heart disease. This is a new finding to show that ABCG1 contributes to protect a progression of atherosclerosis.

在 ATP 结合盒转运蛋白 (ABC) G1 启动子中发现了一个新的 -257T>G 单核苷酸多态性 (SNP)。 -257T>G SNP 降低了 ABCG1 的体外转录活性。在ABCG1 -257T>G SNP的临床分析中，虽然ABCG1与血浆胆固醇水平无关，但表明ABCG1对缺血性心脏病患者的脂蛋白组成如HDL颗粒有影响。这是一项新发现，表明 ABCG1 有助于保护动脉粥样硬化的进展。

项目成果

Identification and Cloning of Novel Soluble and Membrane Bound Forms of The Human ATP-Binding Cassette Transporter G4.

人 ATP 结合盒转运蛋白 G4 的新型可溶性和膜结合形式的鉴定和克隆。

• 发表时间: 2010
• 作者: Y. Uehara;S. Abe;E. Yahiro;A. Kawamura;T. Iwamoto;SI. Miura;K. Saku
• 通讯作者: K. Saku

A Severity of Coronary Artery Disease is influenced by ATP-binding Cassette Transporter G1(ABCG1) -257T>G Promoter Polymorphism.

冠状动脉疾病的严重程度受 ATP 结合盒转运蛋白 G1(ABCG1) -257T>G 启动子多态性的影响。

• 发表时间: 2008
• 作者: Uehara Y;Funlyama S;Abe S;Okamura K;Miura S;Iwamoto T;Saku K.
• 通讯作者: Saku K.

Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells

• DOI: 10.1038/hr.2009.205
• 发表时间: 2010-02-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Fujimi, Kanta;Uehara, Yoshinari;Urata, Hidenori
• 通讯作者: Urata, Hidenori

Newly developed PPAR-alpha agonist (R)-K-13675 inhibits the secretion of inflammatory markers without affecting cell proliferation or tube formation.

• DOI: 10.1016/j.atherosclerosis.2008.05.055
• 发表时间: 2009-03
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: K. Kitajima;Shin-Ichiro Miura;Y. Mastuo;Y. Uehara;K. Saku

ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain.

ATP 结合盒转运蛋白 G4 在阿尔茨海默病大脑的小胶质细胞中高度表达。

• 发表时间: 2008
• 期刊: Brain Res 1217C
• 作者: Uehara Y;Yamada T;Baba Y;Miura SI;Abe S;Kitajima K;Higuchi MA;Iwamoto T;Saku K.
• 通讯作者: Saku K.