Establishment of a novel therapeutic strategyfor atherosclerosis via soluble lipid transporter.

通过可溶性脂质转运蛋白建立动脉粥样硬化的新治疗策略。

• 批准号: 22590832
• 负责人: UEHARA Yoshinari
• 金额: $ 2.83万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590832/
• 关键词: 分子血管病態学; 脂質; 臨床; リポ蛋白; コレステロール; 膜輸送体; 動脈硬化; 低比重リポ蛋白; 虚血性心臓病

Our previous report shows the microglial ATP-binding cassette transporter(ABC) G4 has been upregulated in Alzheimer's disease (AD) brain. We had reported the cloning of a novel isoform of human ABCG4 which was short-isoform (SI) of ABCG4. SI-ABCG4 transfected cells expressed SI-ABCG4 proteins with both soluble and membrane bound forms. The SI-ABCG4 is possible to suppress HDL-mediated cholesterol efflux to interact with other lipid transporters such as ABCG1, ABCG4, and ABCA1. SI-ABCG4 could be a therapeutic tool and a novel marker foratherosclerosis related diseases.

我们以前的报告显示，小胶质细胞ATP结合盒转运蛋白（ABC）G4在阿尔茨海默病（AD）脑中上调。我们已经报道了一个新的人ABCG 4亚型的克隆，它是ABCG 4的短亚型（SI）。SI-ABCG 4转染细胞表达可溶性和膜结合形式的SI-ABCG 4蛋白。SI-ABCG 4可能抑制HDL介导的胆固醇流出，从而与其他脂质转运蛋白如ABCG 1、ABCG 4和ABCA 1相互作用。SI-ABCG 4可能成为动脉粥样硬化相关疾病的治疗工具和新的标志物。

项目成果

FAMP, A Promising Anti-atherosclerotic Agent Construct Pre-Beta HDL in vitro and in vivo

FAMP，一种有前途的抗动脉粥样硬化剂，体外和体内构建 Pre-Beta HDL

• 发表时间: 2011
• 作者: Y. Uehara;K. Oniki;H. Tanigawa;S. Abe;S. Ando;E. Yahiro;SI. Miura;K. Saku
• 通讯作者: K. Saku

IDENTIFICATION AND CLONING OF NOVEL SOLUBLE AND MEMBRANE BOUND FORMS OF HUMAN ATP-BINDING CASSETTE TRANSPORTER G4

新型可溶性和膜结合形式的人 ATP 结合盒转运蛋白 G4 的鉴定和克隆

• 发表时间: 2010
• 作者: Y.Uehara;S.Abe;E.Yahiro;A.Kawamura;T.Iwamoto;SI.Miura;K.Saku
• 通讯作者: K.Saku

Novel Molecular Imaging of Atherosclerosis with 68Ga-Labeled Apo A-I Mimetic Peptide and PET

使用 68Ga 标记的 Apo A-I 模拟肽和 PET 进行动脉粥样硬化的新型分子成像

• 发表时间: 2013
• 期刊: Circ J
• 影响因子: 3.3
• 作者: Mitsuo Kinugasa;Yoshiyuki Rikitake;Yusuke Kurogane;Fumie Kureha;Seimi Kobayashi;Ken-ichi Hirata;Kawachi E; Uehara Y; Hasegawa K; Yahiro E; Ando S; Wada Y; Yano T; Nishikawa H; Shiomi M; Miura S; Watanabe Y; Saku K
• 通讯作者: Kawachi E; Uehara Y; Hasegawa K; Yahiro E; Ando S; Wada Y; Yano T; Nishikawa H; Shiomi M; Miura S; Watanabe Y; Saku K

FAMP, a novel apoA-I mimetic peptide, suppresses aortic plaque formation through promotion of biological HDL function in ApoE-deficient mice.

• DOI: 10.1161/jaha.113.000048
• 发表时间: 2013-05-24
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Uehara Y;Ando S;Yahiro E;Oniki K;Ayaori M;Abe S;Kawachi E;Zhang B;Shioi S;Tanigawa H;Imaizumi S;Miura S;Saku K
• 通讯作者: Saku K

A Small Peptide of ApoA-I Mimetic Works Anti-Atherosclerotic Effects by the Strength of HDL Function

ApoA-I 模拟小肽通过增强 HDL 功能发挥抗动脉粥样硬化作用

• 发表时间: 2012
• 作者: Y Uehara;K Oniki;T Shimizu;H Tanigawa;S Abe;S Ando;E Yahiro;S Imaizumi;S Miura;K Saku
• 通讯作者: K Saku