Establishment of a novel therapeutic strategyfor atherosclerosis via soluble lipid transporter.
Establishment of a novel therapeutic strategyfor atherosclerosis via soluble lipid transporter.
批准号:
22590832
负责人:
UEHARA Yoshinari
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Our previous report shows the microglial ATP-binding cassette transporter(ABC) G4 has been upregulated in Alzheimer's disease (AD) brain. We had reported the cloning of a novel isoform of human ABCG4 which was short-isoform (SI) of ABCG4. SI-ABCG4 transfected cells expressed SI-ABCG4 proteins with both soluble and membrane bound forms. The SI-ABCG4 is possible to suppress HDL-mediated cholesterol efflux to interact with other lipid transporters such as ABCG1, ABCG4, and ABCA1. SI-ABCG4 could be a therapeutic tool and a novel marker foratherosclerosis related diseases.
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FAMP, A Promising Anti-atherosclerotic Agent Construct Pre-Beta HDL in vitro and in vivo
FAMP,一种有前途的抗动脉粥样硬化剂,体外和体内构建 Pre-Beta HDL
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Y. Uehara, K. Oniki, H. Tanigawa, S. Abe, S. Ando, E. Yahiro, SI. Miura, K. Saku]
通讯作者:
K. Saku
IDENTIFICATION AND CLONING OF NOVEL SOLUBLE AND MEMBRANE BOUND FORMS OF HUMAN ATP-BINDING CASSETTE TRANSPORTER G4
新型可溶性和膜结合形式的人 ATP 结合盒转运蛋白 G4 的鉴定和克隆
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Y.Uehara, S.Abe, E.Yahiro, A.Kawamura, T.Iwamoto, SI.Miura, K.Saku]
通讯作者:
K.Saku
Novel Molecular Imaging of Atherosclerosis with 68Ga-Labeled Apo A-I Mimetic Peptide and PET
使用 68Ga 标记的 Apo A-I 模拟肽和 PET 进行动脉粥样硬化的新型分子成像
DOI:
--
发表时间:
2013
期刊:
Circ J
影响因子:
3.3
作者:
[Mitsuo Kinugasa, Yoshiyuki Rikitake, Yusuke Kurogane, Fumie Kureha, Seimi Kobayashi, Ken-ichi Hirata, Kawachi E; Uehara Y; Hasegawa K; Yahiro E; Ando S; Wada Y; Yano T; Nishikawa H; Shiomi M; Miura S; Watanabe Y; Saku K]
通讯作者:
Kawachi E; Uehara Y; Hasegawa K; Yahiro E; Ando S; Wada Y; Yano T; Nishikawa H; Shiomi M; Miura S; Watanabe Y; Saku K
DOI:
10.1161/jaha.113.000048
发表时间:
2013-05-24
期刊:
Journal of the American Heart Association
影响因子:
5.4
作者:
[Uehara Y, Ando S, Yahiro E, Oniki K, Ayaori M, Abe S, Kawachi E, Zhang B, Shioi S, Tanigawa H, Imaizumi S, Miura S, Saku K]
通讯作者:
Saku K
A Small Peptide of ApoA-I Mimetic Works Anti-Atherosclerotic Effects by the Strength of HDL Function
ApoA-I 模拟小肽通过增强 HDL 功能发挥抗动脉粥样硬化作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Y Uehara, K Oniki, T Shimizu, H Tanigawa, S Abe, S Ando, E Yahiro, S Imaizumi, S Miura, K Saku]
通讯作者:
K Saku
共 9 条
Beneficial effects of aerobic exercise on HDL metabolism and cellular mitochondria function by an improvement of HDL function.
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批准号:17K01772
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2017
-
负责人:UEHARA Yoshinari
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依托单位:
A novel function of membrane cholesterol transporter and a therapeutic strategy for atherosclerosis
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批准号:19590874
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2007
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负责人:UEHARA Yoshinari
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依托单位:
海外基金