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Development of hybrid kidney for removal of protein-bound anionic uremic toxins

Development of hybrid kidney for removal of protein-bound anionic uremic toxins
开发用于去除蛋白质结合阴离子尿毒症毒素的混合肾
批准号:
19590961
负责人:
TSURUOKA Shuichi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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中文摘要
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英文摘要
We developed hybrid kidney with renal cell over-expressed human organic anion transporters. We found that this system can selectively remove protein-bound uremic toxins, such as indoxyl sulfate, in animal model of chronic renal failure. We also found that some protein-bound uremic toxins directly stimulate proliferation of vascular smooth muscle cells in vitro.
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Drug interaction between celecoxib and methotrexate in organic anion transporter 3-transfected renal cells and in rats.
塞来考昔和甲氨蝶呤在有机阴离子转运蛋白 3 转染的肾细胞和大鼠中的药物相互作用。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Maeda A, Tsuruoka S]
通讯作者: Tsuruoka S
Dosing Time-Dependent Variation of Bone Resorption by Cyclosporin A in Rats Femurs
环孢素 A 在大鼠股骨中骨吸收的给药时间依赖性变化
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Tsuruoka S, Kaneko S, Yamagata K, Fujimura A.]
通讯作者: Fujimura A.
Erythropoietin-related cGMP production inversely correlated with the ratio of EPO receptor subtype mRNA in circulating endothelial progenitor cells of HD patients and HUVECs.
促红细胞生成素相关的 cGMP 产生与 HD 患者和 HUVEC 循环内皮祖细胞中 EPO 受体亚型 mRNA 的比例呈负相关。
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Ioka T., Tsuruoka S.]
通讯作者: Tsuruoka S.
DOI: 10.1016/j.ejphar.2010.08.053
发表时间: 2010-12
期刊: European journal of pharmacology
影响因子: 5
作者: [Tae Kaneda;S. Tsuruoka;A. Fujimura]
通讯作者: Tae Kaneda;S. Tsuruoka;A. Fujimura
24
    Development of artificial kidney for removal of anionic uremic toxins
    Regulation of acid secretion in cortical collecting duct : An Effect Mediated by Hensin.
    • 批准号:
      14571032
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2002
    • 负责人:
      TSURUOKA Shuichi
    • 依托单位:
    海外基金