Chronic kidney disease (CKD) as a risk factor for cardiovascular diseases: investigation on pathogenesis and development of therapeutic strategy
Chronic kidney disease (CKD) as a risk factor for cardiovascular diseases: investigation on pathogenesis and development of therapeutic strategy
批准号:
19590969
负责人:
KASHIHARA Naoki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
本邦で慢性腎臓病(Chronic Kidney Disease : CKD)が増加している。その主因は糖尿病、肥満、メタボリックシンドローム等の生活習慣病の増加と高齢化である。CKDは腎不全をもたらすだけでなく、心血管病(CVD)の強い危険因子でもある。本研究では、まずCKDの発症・進展機構の詳細を解明した。特になぜアルブミン尿が出現しCVDを合併するのか、その機構を明らかにした。本研究で得られたCKDの基盤病態の理解は、本症の予防と治療法立案に貢献するものである。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Angiotensin II Type 1 Receptor Blocker Ameliorates Uncoupled Endothelial Nitric Oxide Synthase in Rats with Streptozotocine Induced Diabetic Nephropathy
血管紧张素 II 1 型受体阻滞剂可改善链脲佐菌素诱发的糖尿病肾病大鼠的解偶联内皮一氧化氮合酶
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Satoh M, Fujimoto S, Haruna Y, Yada T,Kuwabara A, Nagasu H,Yorimitsu D, Namikoshi T, Tomita N, Sasaki T, Kashihara N]
通讯作者:
Kashihara N
DOI:
10.1007/s10157-007-0011-8
发表时间:
2008-04-01
期刊:
CLINICAL AND EXPERIMENTAL NEPHROLOGY
影响因子:
2.3
作者:
[Kobayashi, Shinya, Satoh, Minoru, Kashihara, Naoki]
通讯作者:
Kashihara, Naoki
Azelnidipin Prevent Renal Dysfunction in Dahl Salt-Sensitive Rats by Suppression of Sympathetic Nerve sysytem
阿折地平通过抑制交感神经系统预防达尔盐敏感大鼠的肾功能障碍
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nagasu H, Satoh M, Kuwabara A, Yorimitsu D, Namikoshi T, Tomita N,Sasaki T, Kashihara N]
通讯作者:
Kashihara N
DOI:
10.1291/hypres.31.745
发表时间:
2008-04-01
期刊:
HYPERTENSION RESEARCH
影响因子:
5.4
作者:
[Namikoshi, Tamehachi, Tomita, Naruya, Kashihara, Naoki]
通讯作者:
Kashihara, Naoki
C/EBP- beta modulates transcription of tubuleinterstitial nephritis antigen in obstructive uropathy
C/EBP-β 调节梗阻性尿路病中肾小管间质性肾炎抗原的转录
DOI:
--
发表时间:
2009
期刊:
J Am Soc Nephrol 20
影响因子:
--
作者:
[Xie P, Sun L, Nayak B, Haruna Y, Liu FY, Kashihara N, Kanwar YS]
通讯作者:
Kanwar YS
共 22 条
Development of the novel in vivo bio-imaging technique to visualize microcirculation of pancreatic islet and its application to elucidate the pathogenesis of diabetes
-
批准号:25560215
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:KASHIHARA Naoki
-
依托单位:
Investigation on the mechanisms of association of chronic kidney disease(CKD) and cardiovascular diseases.
-
批准号:21591047
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:KASHIHARA Naoki
-
依托单位:
Implication of reactive oxygen species, nitric oxide, and their imbalance in the pathogenesis of chronic kidney disease
-
批准号:17590852
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:KASHIHARA Naoki
-
依托单位:
Glomerular endothelial dysfunction in progressive renal diseases and aging kidney and development the novel therapeutic strategy
-
批准号:15590867
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:KASHIHARA Naoki
-
依托单位:
Possible implication of oxidative damages of mitochondria and mitochondrial DNA in the progressive renal injuries
-
批准号:13671130
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.83万
-
财政年份:2001
-
负责人:KASHIHARA Naoki
-
依托单位:
Activation mechanism of NF-kB and development of therapeutic strategy through its regulation.
-
批准号:11671061
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:1999
-
负责人:KASHIHARA Naoki
-
依托单位:
The role of NF-kB in the pathogenesis of glomerulonephritis and therapeutic strategy through its regulation.
-
批准号:09671167
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:1997
-
负责人:KASHIHARA Naoki
-
依托单位:
Phenotypic change of mesangial cells in the glomerulosclerosis
-
批准号:05670955
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1993
-
负责人:KASHIHARA Naoki
-
依托单位:
海外基金