Development of the novel in vivo bio-imaging technique to visualize microcirculation of pancreatic islet and its application to elucidate the pathogenesis of diabetes

点击翻译按钮获取中文摘要

Pancreatic beta cell dysfunction and its progressive loss are the main causative mechanisms of diabetes. Deterioration of microcirculation of islet blood flow could be involved in this mechanism. We have successfully developed a novel technique by which we could visualize microcirculation of pancreatic islet. We hypothesized that angiotensin II directly regulates the pancreatic islet microcirculation and thereby regulates insulin secretion. Angiotensin II significantly induced blood vessel contraction in the islets in a dose-dependent manner. In contrast, the angiotensin type 1 receptor blocker induced vasodilation. Glucose-stimulated insulin secretion was decreased by angiotensin II infusion. These results show that angiotensin II is involved in the regulation of pancreatic islet microcirculation and insulin secretion.We expect this novel technique could contribute to delineate the pathogenesis of diabetes and develop therapeutic strategy for diabetes.